Evidence map›Paper›PMID 40498116›Full record

Trial reportEuropean journal of nutrition2025

Daily profiles of plasma short-chain fatty acids after the intake of three different cereal fibers: a randomized controlled study.

Giuseppina Costabile, Marilena Vitale, Roberta Testa, Annamaria Rivieccio, Marie Palmnäs, Patricia Lopez-Sanchez, Rikard Landberg, Gabriele Riccardi, Rosalba Giacco

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05443828 (Short-chain Fatty Acids in Plasma After Intake of Fermentable Cereal Fibres- An Extended Postprandial Study), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05443828 nacompletednot on this map

Short-chain Fatty Acids in Plasma After Intake of Fermentable Cereal Fibres- An Extended Postprandial Study

TypeinterventionalSponsorFederico II UniversityRan2021 to 2022Enrolled22ConditionsOverweight and ObesityArmsBreakfast Control Meal, Breakfast Test Meal
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giuseppina CostabileDepartment of Clinical Medicine and Surgery, Federico II University, Via Pansini 5, 80131, Naples, Italy. giuseppina.costabile@unina.it.ORCID http://orcid.org/0000-0001-5761-8002
Marilena VitaleDepartment of Clinical Medicine and Surgery, Federico II University, Via Pansini 5, 80131, Naples, Italy.
Roberta TestaDepartment of Clinical Medicine and Surgery, Federico II University, Via Pansini 5, 80131, Naples, Italy.
Annamaria RivieccioDepartment of Clinical Medicine and Surgery, Federico II University, Via Pansini 5, 80131, Naples, Italy.
Marie PalmnäsDepartment of Life Sciences, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden.
Patricia Lopez-SanchezDepartment of Analytical Chemistry, Nutrition and Food Science, University of Santiago de Compostela, Santiago, Spain.
Rikard LandbergDepartment of Life Sciences, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden.
Gabriele RiccardiDepartment of Clinical Medicine and Surgery, Federico II University, Via Pansini 5, 80131, Naples, Italy.
Rosalba GiaccoInstitute of Food Sciences, National Research Council, Avellino, Italy.

Funding

Joint Programming Initiative A healthy diet for a healthy life 727565
6 · The paper itself

Abstract

purposeTo evaluate plasma short-chain fatty acids (SCFA) profiles after the acute intake of cereal fibers in overweight individuals.

methodsIn a randomized, controlled cross-over study, twenty overweight/obese individuals, 30-75 years, consumed at one-week interval three products, each containing 11 g fiber (arabinoxylan (AX), wheat bran or cellulose) during a standard breakfast meal. Plasma samples were collected at fasting, for 8-h after breakfast and on the following morning. SCFAs were measured by LC-MS/MS.

resultsPlasma acetate, propionate and butyrate increased after the three test fibers (p = 0.0001, time effect). The acetate peak was observed between 300 and 360 min after all test fibers (p < 0.05-0.003). Propionate increased significantly by 60 min after AX (p = 0.017) and wheat bran (p = 0.036) while butyrate increased only after AX (p = 0.038). A second peak was observed for propionate at 390 min after AX (p = 0.065) and wheat bran (p = 0.037) and for butyrate only after wheat bran (p = 0.024), remaining above baseline until the morning after. No significant difference was observed between the average daily plasma concentrations of acetate, propionate and butyrate. A very high inter- and intra-subjects' variability of SCFA response was observed. Cluster analysis identified high and low SCFA producers after fiber ingestion among the study participants.

conclusionsAfter fiber ingestion plasma kinetics of acetate differ from those of butyrate and propionate. Among the tested fibers, AX and wheat bran show a better intestinal fermentation ability than cellulose. Heterogeneity in the fermentation ability exists among study participants, with half of them having a minimal SCFA increase after fiber ingestion. CLINICAL TRIAL REGISTRY NUMBER: NCT05443828; https://classic. CLINICALTRIALS: gov/ct2/show/NCT05443828.

Indexed as

Dietary FiberEdible GrainFatty Acids, VolatileAcetatesAdultAgedBreakfastButyratesCelluloseCross-Over StudiesFemaleHumansMaleMiddle AgedObesityOverweightAcetatesarabinoxylanButyratesCelluloseDietary FiberFatty Acids, VolatilePropionatesXylansArabinoxylanCelluloseCereal fiberShort-chain fatty acidsWheat bran

Identifiers

PMID40498116

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.