Evidence map›Paper›PMID 40498128›Full record

SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025

Risk factors for refracture or new vertebral compression fractures after percutaneous vertebroplasty: a systematic review and meta-analysis.

Eleni Marselou, Alexios Kelekis, Zacharias Dimitriadis, George A Koumantakis

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eleni MarselouPhysiotherapy Department, University of West Attica, Agiou Spyridonos 28, 12243, Athens, Greece. emarselou@uniwa.gr.ORCID http://orcid.org/0009-0007-7873-9998
Alexios Kelekis2nd Department of Radiology, University General Hospital "ATTIKON", Medical School, National and Kapodistrian University of Athens, 1 Rimini St, 12462, Haidari, Athens, Greece.
Zacharias DimitriadisPhysiotherapy Department, University of Thessaly, 3rd km Old National Road Lamia-Athens , Lamia, 35132, Greece.
George A KoumantakisPhysiotherapy Department, University of West Attica, Agiou Spyridonos 28, 12243, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsteoporotic vertebral compression fractures can substantially affect a patient's life. Percutaneous vertebroplasty is a minimally invasive surgical procedure that can stabilize fractures, reduce pain, and increase the patient's functionality. However, the incidence of secondary fractures post-surgery requires scientific attention. The risk factors that may lead to a new fracture postoperatively must be identified. PURPOSE: To explore the possible risk factors that can predispose to a subsequent fracture after percutaneous vertebroplasty in patients with osteoporotic vertebral compression fractures. STUDY

designSystematic review and meta-analysis.

methodsWe systematically searched MEDLINE (PubMed), Embase (ScienceDirect), PEDro, and Cochrane databases from July 2013 through May 2024. The extracted data included patient and clinical characteristics, secondary fractures as the primary outcome, and prognostic factors. Eligible studies for synthesis included one group of patients who had suffered a new fracture after surgery and a group of patients who did not suffer any fracture after vertebroplasty ("non fracture group"). We used the software Medcalc and the web program Meta-Mar for all statistical analyses. SMDs were calculated for continuous data, and ORs were calculated for dichotomous data, both with 95% CI. To quantify statistical heterogeneity across studies, we used chi-squared tests and I2 statistics). The Newcastle-Ottawa Scale was used to assess the quality of studies.

resultsA total of 3.821 patients from nine studies were included. Median follow-up was 21 months, and overall secondary fracture incidence was 16.6%. The meta-analysis showed that female gender [OR = 1.62, 95% CI 1,26; 2.07, z = 3.79, P = 0.0001], low bone mineral density [SMD = -0,30, 95% CI -0.52; -0.08, z = -2.65, P = 0.008], smoking [OR = 1.62, 95% CI 1.22; 2.15, z = 3.32, P = 0.001] and type 2 diabetes [OR = 1.40, 95% CI 1.11; 1.76, z = 2.83, P = 0.005] were significant risk factors for the secondary fractures after percutaneous vertebroplasty.

conclusionPatients with these identified risk factors should be monitored and treated accordingly to achieve the optimum prognosis after surgery.

Indexed as

Fractures, CompressionOsteoporotic FracturesSpinal FracturesVertebroplastyHumansPostoperative ComplicationsRecurrenceRisk FactorsAdjacent fracturesOsteoporotic vertebral compression fracturePercutaneous vertebroplastyPrognosisRandomized controlled trialRecollapseRefractureRisk factors

Identifiers

PMID40498128
PMCPMC12373679

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.