ArticleMolecular biology reports2025
Antidepressant effects of fluoxetine: upregulation of connexin 36 and 43 in the hippocampus, prefrontal cortex, and amygdala.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Article
- Serotonin Signaling Pathway Modulation Affects Retinal Neuron Survival in Experimental Model of Retinal Ischemia.Life (Basel, Switzerland) · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMajor depressive disorder is a prevalent and debilitating psychiatric condition. Understanding its molecular mechanisms can aid in the development of more effective treatments. Gap junctions (GJs), composed of connexin (CX) proteins, facilitate direct intercellular communication and have been implicated in the pathophysiology of depression. In particular, connexin 36 (CX36) and connexin 43 (CX43) play key roles in neuronal and glial interactions, respectively. This study aimed to investigate whether fluoxetine modulates the expression of CX36 and CX43 in specific limbic regions, including the ventral hippocampus (v Hip), medial prefrontal cortex (m PC), and basolateral amygdala (BLA) of rats subjected to chronic unpredictable stress (CUS). METHODS AND
resultsAdult male Wistar rats (n = 7 per group) were assigned to control, CUS, and CUS + fluoxetine groups. Our results revealed that CX36 expression was significantly reduced in the v Hip and m PC of CUS rats (P < 0.05), while CX43 expression was significantly lower in all examined brain regions compared to controls (P < 0.05, P < 0.001). Fluoxetine administration significantly upregulated both CX36 and CX43 expression across all regions compared to the CUS group (P < 0.05).
conclusionsThese findings suggest that fluoxetine may exert part of its antidepressant effects by modulating gap junction communication, highlighting a potential novel mechanism for fluoxetine action in depression.
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