Evidence map›Paper›PMID 40498199›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Untargeted Metabolomics of Human Embryonic Kidney (HEK) Cell Line.

Xing Du, Claudia Gomez, Susanna Li, Emily Dorairaj, Samyak Jain, Sanjoy K Bhattacharya

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xing DuBascom Palmer Eye Institute, Miami Integrative Metabolomics Research Center, University of Miami, Miami, FL, USA.
Claudia GomezBascom Palmer Eye Institute, Miami Integrative Metabolomics Research Center, University of Miami, Miami, FL, USA.
Susanna LiBascom Palmer Eye Institute, Miami Integrative Metabolomics Research Center, University of Miami, Miami, FL, USA.
Emily DorairajBascom Palmer Eye Institute, Miami Integrative Metabolomics Research Center, University of Miami, Miami, FL, USA.
Samyak JainBascom Palmer Eye Institute, Miami Integrative Metabolomics Research Center, University of Miami, Miami, FL, USA.
Sanjoy K BhattacharyaBascom Palmer Eye Institute, Miami Integrative Metabolomics Research Center, University of Miami, Miami, FL, USA. SBhattacharya@med.miami.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human embryonic kidney (HEK) cells' low maintenance and quick proliferation make it an ideal target to begin cellular research. Current literature on the metabolomic changes in the fatty acids synthesis (FAS) process is sparse. Thus, inhibition of the pathway in extensively researched HEK cells would provide further insight into upregulation and downregulation of metabolites. Liquid chromatography-mass spectrometry allows for highly sensitive quantification and qualification to provide a comprehensive understanding of the metabolomic changes that can be applied to specialized cell types.

Indexed as

MetabolomeMetabolomicsChromatography, LiquidFatty AcidsHEK293 CellsHumansMass SpectrometryFatty AcidsFatty acids synthesisHEK cellsLiquid chromatography

Identifiers

PMID40498199

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.