Evidence map›Paper›PMID 40498270›Full record

ReviewInternational journal of hematology2025

Allogeneic hematopoietic cell transplantation for autoinflammatory disorders.

Hirokazu Kanegane, Satoshi Miyamoto, Takahiro Kamiya, Hidenori Ohnishi, Ryuta Nishikomori, Andrew R Gennery, Takehiko Mori

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hirokazu KaneganeDepartment of Child Health and Development, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan. hkanegane.ped@tmd.ac.jp.ORCID http://orcid.org/0000-0002-8696-9378
Satoshi MiyamotoDepartment of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Takahiro KamiyaDepartment of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Hidenori OhnishiDepartment of Pediatrics, Gifu University Graduate School of Medicine, Gifu, Japan.
Ryuta NishikomoriDepartment of Pediatrics and Child Health, Kurume University School of Medicine, Fukuoka, Japan.
Andrew R GenneryGreat North Children's Hospital, Newcastle Upon Tyne, UK.
Takehiko MoriDepartment of Hematology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The understanding of autoinflammatory disorders, which are caused by the dysregulated activation of the innate immune system, has improved with the discovery of new diseases and the expansion of phenotypes. Inflammation can be controlled using immunosuppressive drugs, biological agents, and molecular-targeted therapies. However, some cases remain refractory to treatment, and certain patients experience side effects associated with the long-term use of corticosteroids. Recently, allogeneic hematopoietic cell transplantation (HCT) was reported to improve symptoms in refractory cases. Based on the previous reports, in this review, we discuss the potential of HCT in the treatment of autoinflammatory disorders.

Indexed as

Autoimmune DiseasesHematopoietic Stem Cell TransplantationHereditary Autoinflammatory DiseasesInflammationHumansImmunosuppressive AgentsTransplantation, HomologousImmunosuppressive AgentsAutoinflammatory disorderHematopoietic cell transplantationImmunosuppressive therapyInnate immune systemRefractory inflammation

Identifiers

PMID40498270
PMCPMC12304007

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.