Evidence map›Paper›PMID 40498457›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Keratinocyte-TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch.

Andrew J Crowther, Sakeen W Kashem, Madison E Jewell, Henry Le Chang, Élora Midavaine, Mariela Rosa Casillas, Veronika Danchine, Sian Rodriguez, Artur Kania, Ritchie Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Keratinocyte-TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrew J Crowther *Department Anatomy, University of California, San Francisco, CA 94158.ORCID 0000-0001-9269-6188
Sakeen W Kashem *Department Dermatology, University of California, San Francisco, CA 94158.
Madison E JewellDepartment Anatomy, University of California, San Francisco, CA 94158.ORCID 0009-0004-8337-1583
Henry Le ChangDepartment Anatomy, University of California, San Francisco, CA 94158.ORCID 0009-0003-2064-1198
Élora MidavaineDepartment Anatomy, University of California, San Francisco, CA 94158.ORCID 0000-0002-0364-8975
Mariela Rosa CasillasDepartment Anatomy, University of California, San Francisco, CA 94158.ORCID 0000-0002-8028-4634
Veronika DanchineDepartment Dermatology, University of California, San Francisco, CA 94158.
Sian RodriguezDepartment Anatomy, University of California, San Francisco, CA 94158.
Artur KaniaNeural Circuit Development Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7.ORCID 0000-0002-5209-2520
Ritchie ChenDepartment Neurological Surgery, University of California, San Francisco, CA 94158.
Joao M BrazDepartment Anatomy, University of California, San Francisco, CA 94158.ORCID 0000-0001-8955-0735
Allan I BasbaumDepartment Anatomy, University of California, San Francisco, CA 94158.ORCID 0000-0002-1710-6333

Funding

UCSF Dermatology Training GrantT32AR007175 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wilson Liao, Michael David Rosenblum · 1986 to 2026
$6.1M
Cutaneous opioid circuitry in skin inflammation and sensationK08AR085766 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sakeen W Kashem · 2025 to 2026
$372k
The contribution of chronic pain-associated thalamocortical activity to pain aversivenessF32DE029384 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CROWTHER, ANDREW JOSEPH · 2019 to 2022
$211k
Canadian Government | Canadian Institutes of Health Research (CIHR) PJT-162225 MOP-77556 PJT-153053 PJT-159839HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) 5T32AR007175-13HHS | NIH | National Institute of Dental and Craniofacial Research (NIDR) 5F32DE029384HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NSR35097306NIAMS NIH HHS K08 AR085766NIAMS NIH HHS T32 AR007175NIDCR NIH HHS F32 DE029384NSF (NSF) Graduate Research Fellowship 2034836Open Philanthropy Project Chronic Pain ResearchSandler Foundation PBBRUniversity of California, San Francisco (UCSF) Dermatology Foundation Career Development Award Investigator Research Fellowship
6 · The paper itself

Abstract

Our understanding of neural circuits that respond to skin dysfunction, triggering itch, and pathophysiological scratching remains incomplete. Here, we describe a profound chronic itch phenotype in transgenic mice expressing the tetracycline transactivator (tTA) gene within the Phox2a lineage. Phox2a; tTA mice exhibit intense, localized scratching and regional skin lesions, controllable by the tTA inhibitor, doxycycline. As gabapentin and the kappa opioid receptor agonist, nalfurafine, but not morphine, significantly reduce scratching, this phenotype has a pharmacological profile of neuropathic pruritus. Importantly, the Phox2a; tTA expression occurs in a spatially restricted population of skin keratinocytes that overlaps precisely with the skin area that is scratched. Localized G

Indexed as

KeratinocytesPruritusSensory Receptor CellsTRPV Cation ChannelsAminesAnimalsChronic DiseaseCyclohexanecarboxylic AcidsDisease Models, AnimalGabapentingamma-Aminobutyric AcidHomeodomain ProteinsMiceMice, TransgenicSkinAminesCyclohexanecarboxylic AcidsGabapentingamma-Aminobutyric AcidHomeodomain ProteinsTRPV1 protein, mouseTRPV Cation Channelschronic itchDREADDskeratinocytesneuropathic itchTRPV1 sensory neurons

Identifiers

PMID40498457
PMCPMC12184494

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.