Evidence map›Paper›PMID 40499444›Full record

ArticleInternational journal of surgery case reports2025

Remarkable healing of a severe wound through surgical debridement, honey medicinal application, amniotic membrane, and bovine collagen powder; A case report study.

Mohammad Reza Faramarzi, Mohsen Sayahi, Behnam Babamiri, Navid Faraji, Kamal Rahimi, Salahaddin Ghaderzadeh

Abstract readCase Reports
In one paragraph

Article in International journal of surgery case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammad Reza FaramarziDepartment of Medical-Surgical Nursing, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, West Azerbaijan, Iran.
Mohsen SayahiMSN, School of Nursing and Midwifery, Alborz University of Medical Sciences, Karaj, Iran.
Behnam BabamiriMSN, Department of Critical Care Nursing, Nursing and Midwifery School, Zanjan University of Medical Sciences, Zanjan, Iran.
Navid FarajiMSN, Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Urmia University of Medical Sciences, Urmia, West Azerbaijan, Iran. Electronic address: navidfaraji1993@gmail.com.
Kamal RahimiDepartment of Medicine, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, West Azerbaijan, Iran.
Salahaddin GhaderzadehPhd, Internist specialist, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction and importanceTreating severe wounds presents considerable challenges in contemporary medicine, requiring novel strategies to improve healing and restore tissue integrity. This study examines the efficacy of a comprehensive approach that combines surgical debridement, honey as a medicinal application, amniotic membrane grafting, and bovine collagen powder. CASE PRESENTATION: 20-year-old male experienced significant injuries to his right hand due to a motor vehicle accident. Initial evaluations showed extensive lacerations and necrotic tissue. After stabilizing his condition, the patient underwent surgical debridement to eliminate non-viable tissue, thereby establishing an optimal healing environment. A structured wound care regimen was then initiated, including the use of honey, amniotic membrane, and bovine collagen. DISCUSSION: The therapy combination demonstrated effectiveness. Surgical debridement reduced the risk of infection and created a healthy wound bed. Honey helped retain moisture and displayed antibacterial properties, leading to a notable decrease in inflammation. The amniotic membrane facilitated cell migration and proliferation, thereby promoting tissue regeneration. Bovine collagen contributed to the structural integrity and cellular adhesion, further enhancing healing outcomes. Throughout the treatment, the patient reported significant pain relief.

conclusionThis case highlights the promise of an integrated approach to managing complex wounds. The effective combination of surgical techniques and advanced biological therapies not only adds to the current body of knowledge but also stimulates further investigation into innovative wound care methods.

Indexed as

Amniotic membraneBovine collagenCase reportSurgical debridementWound

Identifiers

PMID40499444
PMCPMC12182374

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.