Evidence map›Paper›PMID 40499544›Full record

ArticleCell reports. Medicine2025

Ultra-wide-field fundus photography and AI-based screening and referral for multiple ocular fundus diseases.

Xinyu Zhao, Xingwang Gu, Da Teng, Xiaolei Sun, Qijie Wei, Bo Wang, Jinrui Wang, Jianchun Zhao, Dayong Ding, Bilei Zhang and 27 more

Abstract read
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Xinyu ZhaoDepartment of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, China and Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Beijing 100730, China.
Xingwang GuDepartment of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, China and Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Beijing 100730, China.
Da TengDepartment of Ophthalmology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Xiaolei SunEye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan, Shandong 250021, China.
Qijie WeiSchool of Information, Renmin University of China, Beijing 100086, China.
Bo WangVistel AI Lab, Visionary Intelligence Ltd, Beijing 100080, China.
Jinrui WangVistel AI Lab, Visionary Intelligence Ltd, Beijing 100080, China.
Jianchun ZhaoVistel AI Lab, Visionary Intelligence Ltd, Beijing 100080, China.
Dayong DingVistel AI Lab, Visionary Intelligence Ltd, Beijing 100080, China.
Bilei ZhangDepartment of Ophthalmology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410000, China.
Yuelin WangDepartment of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, China and Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Beijing 100730, China.
Wenfei ZhangDepartment of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, China and Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Beijing 100730, China.
Shiyu ChengDepartment of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, China and Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Beijing 100730, China.
Xinyu LiuDepartment of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, China and Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Beijing 100730, China.
Lihui MengDepartment of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, China and Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Beijing 100730, China.
Bing LiDepartment of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, China and Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Beijing 100730, China.
Xiao ZhangDepartment of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, China and Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Beijing 100730, China.
Zhengming ShiDepartment of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, China and Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Beijing 100730, China.
Anyi LiangGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510080, China.
Guofang JiaoTonghua Eye Hospital of Jilin Province, Tonghua, Jilin 134001, China.
Huiqin LuDepartment of Ophthalmology, Xi'an NO 1 Hospital, Xian, Shanxi 710000, China.
Changzheng ChenEye Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Rishet AhmatDepartment of Ophthalmology, Bayinguoleng people's Hospital, Korla, Xinjiang 841000, China.
Hao ZhangDepartment of Ophthalmology, The Fourth People's Hospital of Shenyang, China Medical University, Shenyang, Liaoning 110031, China.
Yakun LiDepartment of Ophthalmology, The Second Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075100, China.
Dan ZhuDepartment of Ophthalmology, The Affiliated Hospital of Inner Mongolia Medical University. Huhhot, Inner Mongolia 010050, China.
Han ZhangDepartment of Ophthalmology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, China.
Hongbin LvDepartment of Ophthalmology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
Donglei ZhangDepartment of Ophthalmology, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi 030012, China.
Mengda LiEye Center, Beijing Tsinghua Changgung Hospital, China and School of Clinical Medicine, Tsinghua University, Beijing 100084, China.
Ziwu ZhangDepartment of Ophthalmology, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China.
Ling YuanDepartment of Ophthalmology, The First Affiliated Hospital of Kunming Medical University, Kunming,Yunnan 650032, China.
Chang SuDepartment of Ophthalmology, Affiliated hospital of Chengde medical university, Chengde medical university, Chengde, Hebei 067000, China.
Dawei SunDepartment of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China.
Qiuming LiDepartment of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Dawa XiaoTibet Autonomous Region People's Hospital of Ophthalmology, Tibet Autonomous Region, Lhasa 850000, China.
Youxin ChenDepartment of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, China and Key Lab of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address: chenyx@pumch.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To address the difficulty in comprehensive screening of fundus diseases, we develop three deep learning algorithms (DLAs) based on different algorithms (Swin Transformer and cross-domain collaborative learning [CdCL]) and imaging modalities (ultra-wide-field [UWF] images and the cropped posterior-pole-region [PPR] images) to identify 25 fundus conditions and provide referral suggestions: WARM (CdCL + UWF images), BASE (Swin Transformer + UWF images), and WARM-PPR (CdCL + PPR images). 59,475 UWF images are included to establish internal and external datasets. WARM shows the best performance on the internal test (area under the receiver operating characteristic curve [AUC] for screening = 0.915; AUC for referral = 0.911) and the external multi-center test (AUC for screening = 0.912; AUC for referral = 0.902). UWF images and the CdCL approach significantly enhance the DLA's ability to detect abnormalities in the peripheral retina. The WARM model shows promise as a reliable and accurate tool for comprehensive fundus screening on a large scale.

Indexed as

Fundus OculiPhotographyRetinal DiseasesAlgorithmsArea Under CurveDeep LearningFemaleHumansMaleReferral and ConsultationROC Curveartificial intelligencedeep learningocular fundus diseasesreferralscreeningultra-wide-field fundus images

Identifiers

PMID40499544
PMCPMC12208325

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.