ArticleMolecular cell2025
Vostok: A looping factor for the organization of the regulatory genome in the Drosophila brain.
Article in Molecular cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Mechanisms and functional implications of long-range enhancer-dependent gene regulation.Nature genetics · 2026Review
- Transcription factors as drivers of 3D enhancer-promoter interactions.Current opinion in structural biology · 2026Review
- Reversing aging-like 3D genome disorganization in abioRxiv : the preprint server for biology · 2026Article
- The Semantics and Mechanisms of Enhancers and Promoters: "What Is True forAnnual review of biochemistry · 2026Review
- Looping specificity of Polycomb response elements requires GAF and a combination of looping factors that could form a code.Nucleic acids research · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
Drosophila tethering elements mediate long-range enhancer-promoter interactions and connect the promoters of distant paralogous genes. Micro-C maps identified 645 such loops in the Drosophila larval brain, spanning distances of 25 to 250 kb. Here, we demonstrate that the MADF-containing Vostok protein acts as a looping factor. It binds to GCAACA motifs that are overrepresented in brain tethering elements. There is a loss of 47 (7%) of the loops in Vostok mutants, resulting in diminished expression of associated genes. Vostok is largely independent of another looping factor, GAGA-associated factor (GAF). Only 9 loops are disrupted in both Vostok and GAF mutants, raising the possibility of a combinatorial code for tether-tether interactions. This is supported by the reliance of two previously identified meta-loops spanning 6 Mb on both GAF and Vostok. We discuss the prospects of using different combinations of looping factors to engineer 3D associations in animal genomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.