Evidence map›Paper›PMID 40500338›Full record

ArticleMolecular psychiatry2025

White matter disconnection in acquired criminality.

Isaiah Kletenik, Christopher M Filley, Alexander L Cohen, William Drew, Patricia S Churchland, R Ryan Darby, Michael D Fox

Abstract read
In one paragraph

Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Forensic neuropathology: 2026 update.Free neuropathology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Isaiah KletenikDepartment of Neurology, Brigham and Women's Hospital, Boston, MA, USA. ikletenik@bwh.harvard.edu.ORCID http://orcid.org/0000-0001-7706-967X
Christopher M FilleyDepartments of Neurology and Psychiatry, and Behavioral Neurology Section, University of Colorado School of Medicine, Aurora, CO, USA.
Alexander L CohenCenter for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6557-5866
William DrewDepartment of Neurology, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9178-8731
Patricia S ChurchlandDepartment of Philosophy, University of California San Diego and Salk Institute, San Diego, CA, USA.
R Ryan Darby *Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael D Fox *Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8848-6399

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Using human brain connectivity to identify the causal neuroanatomical substrate of depression symptomsR01MH113929 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL D FOX · 2017 to 2026
$6.9M
Repetitive TMS-induced modulation of cortical excitability in ADR01MH115949 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHAFI, MOUHSIN · 2018 to 2022
$3.2M
Treating hyperexcitability in Alzheimer’s disease with levetiracetam to improve brain function and cognitionR01AG060987 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHAFI, MOUHSIN · 2019 to 2023
$3.0M
Transdiagnostic memory, mood and motor circuits in Alzheimer's and neurodegenerative diseaseR56AG069086 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI FOX, MICHAEL D · 2021 to 2021
$873k
Cognitive and Neural Mechanisms of Antisocial Behavior in Frontotemporal DementiaK23AG070320 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DARBY, RICHARD RYAN · 2021 to 2025
$857k
The neuroanatomical basis for face processing deficits in autism spectrum disorderK23MH120510 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI COHEN, ALEXANDER LI · 2020 to 2023
$779k
Targeted modulation of symptom-specific brain circuits with transcranial magnetic stimulationR21MH126271 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI FOX, MICHAEL D · 2021 to 2022
$492k
NIA NIH HHS K23 AG070320NIA NIH HHS R01 AG060987NIA NIH HHS R56 AG069086NIMH NIH HHS K23 MH120510NIMH NIH HHS R01 MH113929NIMH NIH HHS R01 MH115949NIMH NIH HHS R21 MH126271NIMH NIH HHS U54 MH091657NINDS NIH HHS L30 NS134024U.S. Department of Health & Human Services | NIH | Division of Loan Repayment (DLR) L30NS134024U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) K23MH120510U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH113929U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH115949U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21MH126271U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) K23AG070320-01A1U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R56AG069086
6 · The paper itself

Abstract

Structural brain imaging is increasingly introduced as evidence in criminal trials. A key imaging abnormality identified in criminal populations is alteration to the right uncinate fasciculus but it remains unclear whether these changes play a causal role in criminal behavior. Lesion studies of acquired criminality offer the opportunity to assess the causal role of focal disruption of specific white matter connections in criminal behavior. We studied lesion locations of focal brain damage associated with new onset criminal behavior compared to lesions associated with 21 diverse neuropsychiatric symptoms. First, we analyzed the intersection of lesion locations with an atlas-based right uncinate fasciculus. Second, we assessed the intersection of lesion locations with all white matter tracts from this atlas. Third, we performed a connectome-based analysis of all possible white matter connections with each lesion location, without a priori assumptions regarding specific tracts. We repeated all analyses limited to subjects who committed violent crimes. Lesions associated with criminality intersected the right uncinate more than lesions associated with other neuropsychiatric symptoms (p = 4.78 × 10

Indexed as

Criminal BehaviorWhite MatterAdultBrainConnectomeCrimeCriminalsDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeural Pathways

Identifiers

PMID40500338
PMCPMC12709597

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.