ArticleJournal of neural transmission (Vienna, Austria : 1996)2025
Dysregulated responses to stress and alcohol cues in cortico-striatal-limbic regions in social drinkers with early trauma.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Early trauma (ET) is associated with negative health outcomes, including elevated risk for stress- and alcohol-related disorders. Previous research highlights stress-related neural correlates of ET. However, neural correlates of ET during alcohol cue response remain understudied, particularly in social drinkers. The present study seeks to examine neurobehavioral responses to stress and alcohol cues in social drinkers with and without ET, aiming to elucidate neural mechanisms linking ET and risk for future alcohol misuse. Sixty-four social alcohol users completed a baseline assessment, eligibility determination, ET classification, and an emotion provocation task involving stressful, alcohol-related, and neutral cue exposure during functional magnetic resonance imaging (fMRI) scanning. ET individuals showed significantly greater levels of stress and alcohol craving ratings at baseline compared to NT individuals. During stress cues, ET individuals exhibited decreased activity in regulatory prefrontal regions (ventromedial prefrontal cortex (PFC), dorsolateral PFC), but hyperactivity in regions of emotional reactivity (amygdala, hippocampus, and putamen). During alcohol cues, ET individuals showed decreased activity in reward processing regions, including the dorsolateral PFC, anterior PFC, and putamen, but increased activity in the posterior cingulate cortex. Findings indicate that ET individuals exhibit neural responses characterized by decreased prefrontal regulation and altered activation in limbic-striatal subcortical regions during stress and alcohol cues, suggesting dysregulated control over stress and reward processing which may contribute to ET's increased risk for stress and reward-related disorders found in the general population.
Indexed as
Identifiers
40500419What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.