ArticleNature2025
Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Tetramethylpyrazine modulates the Nrf2/JNK axis to intervene in ferroptosis and neuroinflammation after spinal cord injury: an integrated perspective from antioxidant to regenerative therapy.Molecular biology reports · 2026Review
- Metabolism, autophagy, and cell death: The triangular axis in tumor survival and therapeutic resistance.Redox biology · 2026Review
- Ferroptosis in T cells: mechanisms, biology and translational opportunities.Nature reviews. Immunology · 2026Review
- Targeting the CTBP1-CETP axis overcomes ferroptosis resistance in non-small cell lung cancer by altering lipid accumulation.Clinical and translational medicine · 2026Article
- Emerging roles of ferroptosis in modulating the immune landscape of glial tumours.Nature cell biology · 2026Review
- The Redox Paradox of Natural Supplements in Cancer: A Narrative Review to Guide Clinical Practice.Antioxidants (Basel, Switzerland) · 2026Review
- Targeting the lipid desaturation network in cancer: from metabolic plasticity to precision therapeutics.Journal of experimental & clinical cancer research : CR · 2026Review
- Translating ferroptosis into oncology: challenges, opportunities and future directions.Nature reviews. Clinical oncology · 2026Review
- Ascites protects against ferroptosis and enables the peritoneal growth of ovarian cancer.Nature communications · 2026Article
- Arvanil reverses cisplatin resistance in ovarian cancer by activating HMOX1-driven ferroptosis.Scientific reports · 2026Article
- mTORC1 activity suppresses ferroptosis through a SCARB1-dependent HDL-tocopherol uptake pathway.Molecular cell · 2026Article
- Peritumoural adipose tissue promotes ferroptosis resistance by 3-hydroxykynurenine-mediated suppression of ferritinophagy.Nature cell biology · 2026Article
- CA9-related ferroptosis is a potential therapeutic target of kaempferol anti-oral squamous cell carcinoma.Translational cancer research · 2026Article
- Dissecting Complex Interactions Between Ferroptosis and the Proteasome.bioRxiv : the preprint server for biology · 2026Article
- Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis.Nature cell biology · 2026Article
- Lipids grease the chain of cancer progression.Trends in cancer · 2026Review
- Lipid Metabolism Reprogramming in Diffuse Large B-Cell Lymphoma (DLBCL): Mechanisms and Treatment Strategies.Cancers · 2026Review
- Harnessing Cuproptosis resistance to advance cancer therapeutics.Apoptosis : an international journal on programmed cell death · 2026Review
- Ferroptosis in renal cell carcinoma: integrative multi-omics insights and therapeutic perspectives.International journal of surgery (London, England) · 2026Article
- Tocotrienols exhibit superior ferroptosis inhibition over tocopherols.Scientific reports · 2026Article
Corrections and comments
- Update of
Authors and funding
30 authors.
Dylan Calhoon *Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-5818-3773
Lingjie Sang *Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Fubo JiChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Divya BezwadaChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-5434-2976
Sheng-Chieh HsuChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Feng CaiChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-5192-9520
Nathaniel KimChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Amrita BasuComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
Renfei WuChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8847-7254
Anastasia PimentelChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Bailey BrooksChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-5266-9377
Konnor LaLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Ana Paulina SerranoChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Daniel L CassidyChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ling CaiChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Vanina Toffessi-TcheuyapDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-6817-9241
Maryam E MoussaDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.
Winnie UritboonthaiScripps Center for Metabolomics, The Scripps Research Institute, La Jolla, CA, USA.
Linh Truc HoangScripps Center for Metabolomics, The Scripps Research Institute, La Jolla, CA, USA.
Meghana KolliAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Brooklyn JacksonDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Vitaly MargulisDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Gary SiuzdakScripps Center for Metabolomics, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0002-4749-0014
James BrugarolasDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8575-499X
Ian CorbinAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Derek A PrattDepartment of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada.ORCID 0000-0002-7305-745X
Ryan J WeissComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.ORCID 0000-0002-4563-6075
Ralph J DeBerardinisChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-2705-7432
Kıvanç BirsoyLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-7579-9895
Javier Garcia-BermudezChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA. Javier.GarciaBermudez@UTSouthwestern.edu.ORCID 0000-0001-5274-7040
Funding
UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Carlos L Arteaga · 2010 to 2026
$53.7MUniversity of Texas Southwestern Medical Center SPORE in Kidney CancerP50CA196516 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Payal Kapur, Payal Kapur · 2016 to 2026
$24.7MMetabolic Regulators of Tumor Growth and ProgressionR35CA220449 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI RALPH J DEBERARDINIS · 2017 to 2026
$9.4MSingle-Cell & Computational Biology CoreU54CA261701 · NCI · ROCKEFELLER UNIVERSITY · PI Sohail F. Tavazoie · 2021 to 2026
$9.1MUT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4MNational Glycoscience Resource- CCRC Service and Training - NGlycoR@CCRCR24GM137782 · NIGMS · UNIVERSITY OF GEORGIA · PI Parastoo Azadi · 2020 to 2026
$5.2MMetabolomics Technologies to Advance Biomedical ResearchR35GM130385 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI GARY E SIUZDAK · 2019 to 2026
$3.9MConstruction of A Lung Cancer Preclinical Model Cross-comparison PlatformR01CA285336 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Ling Cai · 2024 to 2026
$3.1MThe role of mitochondrial glutathione homeostasis in tumor formationR01CA273233 · NCI · ROCKEFELLER UNIVERSITY · PI Kivanc Birsoy · 2023 to 2026
$1.9MImage Guided Delivery and Evaluation of Low-Density Lipoprotein- Docosahexaenoic acid Nanoparticles for the Management of Hepatocellular Carcinoma -Diversity SupplementR01CA215702 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI CORBIN, IAN RONALD · 2017 to 2021
$1.9MDocosahexaenoic Acid Loaded Low-density Lipoproteins: A Novel Biologic Intervention for Hepatocellular Carcinoma.R01CA271496 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Ian Ronald Corbin · 2023 to 2026
$1.8MInvestigating the molecular mechanisms of glycosaminoglycan assemblyR35GM150736 · NIGMS · UNIVERSITY OF GEORGIA · PI Ryan Joseph Weiss · 2023 to 2026
$1.5MNCI NIH HHS F31 CA239330NCI NIH HHS P30 CA142543NCI NIH HHS P50 CA196516NCI NIH HHS R00 CA248838NCI NIH HHS R01 CA215702NCI NIH HHS R01 CA271496NCI NIH HHS R01 CA273233NCI NIH HHS R01 CA285336NCI NIH HHS R35 CA220449NCI NIH HHS T32 CA291654NCI NIH HHS U54 CA261701NHLBI NIH HHS R21 HL167091NIDDK NIH HHS P30 DK127984NIGMS NIH HHS DP2 GM159178NIGMS NIH HHS R24 GM137782NIGMS NIH HHS R35 GM130385NIGMS NIH HHS R35 GM150736
Abstract
Lipids are essential components of cancer cells due to their structural and signalling roles
Indexed as
FerroptosisGlycosaminoglycansLipoproteinsNeoplasmsalpha-TocopherolAnimalsBiological TransportCarcinoma, Renal CellCell Line, TumorChondroitin SulfatesFemaleHumansKidney NeoplasmsMaleMicealpha-TocopherolChondroitin SulfatesGlycosaminoglycansLipoproteins
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What Socratic holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.