Evidence map›Paper›PMID 40500452›Full record

ArticleNature2025

Brain implantation of soft bioelectronics via embryonic development.

Hao Sheng, Ren Liu, Qiang Li, Zuwan Lin, Yichun He, Thomas S Blum, Hao Zhao, Xin Tang, Wenbo Wang, Lishuai Jin and 13 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Review
  3. Conductive Hydrogels for Exogenous Sensing and Cell Fate Control.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  4. Article
  5. Tissue-bioelectronics interfaces.Chemical Society reviews · 2026
    Review
  6. Article
  7. Full-Stack Architectures for Intelligent Brain-Computer Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  8. Review
  9. Article
  10. Organoid Brain-Machine-Interface Devices for Central Nervous System Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Physical Intelligence in Small-Scale Robots and Machines.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Hao Sheng *John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0001-7477-7830
Ren Liu *John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.
Qiang Li *John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.
Zuwan Lin *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-5786-9768
Yichun HeJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0001-9573-2682
Thomas S BlumJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0003-2598-4483
Hao ZhaoJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.
Xin TangJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0002-1533-2580
Wenbo WangJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0002-4282-2542
Lishuai JinDepartment of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA, USA.
Zheliang WangDepartment of Aerospace Engineering and Engineering Mechanics, The University of Texas at Austin, Austin, TX, USA.
Emma HsiaoJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.
Paul Le FlochJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.
Hao ShenJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0001-8410-5747
Ariel J LeeJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.ORCID 0000-0002-8549-6310
Rachael Alice Jonas-ClossDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.
James BriggsBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Siyi LiuDepartment of Aerospace Engineering and Engineering Mechanics, The University of Texas at Austin, Austin, TX, USA.
Daniel SolomonJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.
Xiao WangBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-3090-9894
Jessica L WhitedDepartment of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-3709-6515
Nanshu LuDepartment of Aerospace Engineering and Engineering Mechanics, The University of Texas at Austin, Austin, TX, USA.
Jia LiuJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA. jia_liu@seas.harvard.edu.ORCID 0000-0003-2217-6982

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Roles of body-wide injury responses in axolotl limb regenerationR01HD115272 · NICHD · HARVARD UNIVERSITY · PI JESSICA L. WHITED · 2024 to 2026
$2.5M
"Building a robust organoid platform to study the developmental potential and physiology of human specific cortical cell types"RF1MH123948 · NIMH · HARVARD UNIVERSITY · PI LIU, JIA, RAMANATHAN, SHARAD · 2020 to 2020
$1.8M
NICHD NIH HHS P50 HD105351NICHD NIH HHS R01 HD115272NIMH NIH HHS RF1 MH123948
6 · The paper itself

Abstract

Developing bioelectronics capable of stably tracking brain-wide, single-cell, millisecond-resolved neural activity in the developing brain is critical for advancing neuroscience and understanding neurodevelopmental disorders. During development, the three-dimensional structure of the vertebrate brain arises from a two-dimensional neural plate

Indexed as

BrainElectrodes, ImplantedElectronicsEmbryonic DevelopmentAnimalsElectric StimulationFemaleMiceMicroelectrodesNeuronsRatsSingle-Cell Analysis

Identifiers

PMID40500452
PMCPMC12975305

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.