Evidence map›Paper›PMID 40500499›Full record

ReviewAdvances in neurobiology2025

Plasticity of Myelination.

Grace Flower, Svenja Vorthmann, Daniel Fulton, Nicola B Hamilton

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Grace FlowerWolfson Sensory, Pain and Regeneration Centre, Institute of Psychiatry, Psychology and Neuroscience, Guy's Campus, King's College, London, UK.
Svenja VorthmannWolfson Sensory, Pain and Regeneration Centre, Institute of Psychiatry, Psychology and Neuroscience, Guy's Campus, King's College, London, UK.
Daniel FultonBirmingham Centre for Neurogenetics, Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Nicola B HamiltonWolfson Sensory, Pain and Regeneration Centre, Institute of Psychiatry, Psychology and Neuroscience, Guy's Campus, King's College, London, UK. nicola.hamilton-whitaker@kcl.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myelin plasticity, the capacity for dynamic changes in myelination and myelin structure, challenges the long-held view of myelin as a static entity post-development. Emerging evidence highlights its pivotal role in adapting neural circuits during learning, memory, and recovery from injury or disease. This chapter explores the cellular and molecular mechanisms underlying myelin plasticity, focusing on activity-dependent and experience-driven myelination mediated by oligodendrocytes, which are potentially modified by astrocytes and microglia. This study examines how neuronal activity regulates oligodendrocyte differentiation and myelin remodelling, affecting conduction velocity and circuit synchronization. The implications of myelin plasticity in cognition, ageing, and pathologies such as multiple sclerosis and stroke are discussed alongside experimental models that elucidate its processes. Finally, the importance of sleep in myelin maintenance and plasticity is discussed. Elucidating the mechanisms underlying myelin plasticity and maintenance may uncover new therapeutic opportunities for treating diseases and injuries that disrupt myelin and neuronal activity.

Indexed as

Myelin SheathNeuronal PlasticityOligodendrogliaAnimalsHumansActivity-dependent myelinationCognition and memoryMyelin dynamicsMyelin plasticityNeuronal circuit adaptationOligodendrocytes

Identifiers

PMID40500499

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.