Evidence map›Paper›PMID 40500552›Full record

ReviewDiscover oncology2025

The role of non-coding RNAs in the regulation of cell death pathways in melanoma.

Yekta Metanat, Maria Sviridova, Bareq N Al-Nuaimi, Fateme Janbazi, Mahtab Jalali, Nogol Ghalamkarpour, Elnaz Khodabandehloo, Ehsan Ahmadi

Abstract readReview
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Innovative immunotherapeutic strategies for thyroid cancer: challenges and opportunities.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  3. Review
  4. Comparative Genomics Reveals Host-Specific Adaptation ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yekta MetanatFaculty of Medicine, Sistan and Baluchestan Province, Zahedan University of Medical Sciences, Zahedan, Iran.
Maria SviridovaDepartment of Infectious DiseaseInstitute of Public Health named after F.F. Erisman, I.M.Sechenov First Moscow State Medical University the Russian Federation (Sechenov University), Moscow, Russian Federation.
Bareq N Al-NuaimiDepartment of Microbiology, College of Medicine, Al-Iraqia University, Baghdad, Iraq.
Fateme JanbaziStudent Research Committee, Babol University of Medical Sciences, Babol, Iran.
Mahtab JalaliShiraz Institute of Stem Cell and Regenerative Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Nogol GhalamkarpourDepartment of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Elnaz KhodabandehlooDepartment of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. elnaz.azimuno@gmail.com.
Ehsan AhmadiDepartment of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Ahmadieh762@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, due to increased exposure to ultraviolet rays, the incidence of melanoma has increased significantly. Despite the progress in early diagnosis and treatment methods, managing metastatic melanoma remains challenging. Resistance to programmed cell death (PCD) is a hallmark of various cancers, including melanoma. This resistance can affect cell growth, survival, metastasis, and resistance to therapies. In recent years, non-coding RNAs (ncRNAs) have been acknowledged as master regulators of various biological processes, including PCD. This regulatory network acts as a double-edged sword in melanoma progression, either promoting tumor survival by preventing PCD or acting as an anti-tumor agent by inducing it. Such diverse functions make ncRNAs invaluable as diagnostic and prognostic biomarkers and potential therapeutic targets. This review explores the multifaceted roles of ncRNAs in regulating different forms of PCD, comprising apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, cuproptosis, and anoikis, highlighting their potential applications in melanoma research and treatment.

Indexed as

Cancer biomarkersMelanomaNcRNA dysregulationNon-coding RNAsProgrammed cell death

Identifiers

PMID40500552
PMCPMC12158911

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.