Evidence map›Paper›PMID 40500729›Full record

ArticleLipids in health and disease2025

Suppression effect of folate on poly- and perfluoroalkyl substance-induced alterations in lipids and the atherogenic index of plasma in adolescents.

Yuxin Pan, Ziye Du, Yuyang Ma, Cheng Chen, Shaoyu He, Manling Zhang, Krishna Baral, Linyong Xu, Mengchang Xu, Mingyi Zhao

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In one paragraph

Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuxin PanDepartment of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Ziye DuDepartment of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Yuyang MaDepartment of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Cheng ChenDepartment of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Shaoyu HeDepartment of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Manling ZhangDepartment of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Krishna BaralDepartment of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China.
Linyong XuHunan Provincial Key Laboratory of Oral Health Research & Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, 410000, , Hunan, China.
Mengchang XuHunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, Changsha Medical University, Changsha, 410219, Hunan,, China.
Mingyi ZhaoDepartment of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, 410013, Hunan, China. zhao_mingyi@csu.edu.cn.

Funding

Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya hospital of Central South University YX202212
6 · The paper itself

Abstract

backgroundThe specific mechanisms by which poly - and polyfluoroalkyl substances (PFAS) influence the particular lipid levels of adolescents and the progression of early subclinical atherosclerosis remain unclear. A certain degree of correlation exists between folate and the exposure of adolescents to PFAS, the maintenance of lipid homeostasis, as well as cardiovascular health status. This study investigated the role and mechanisms of folate in the process through which PFAS can influence the blood lipid profiles of adolescents.

methodsWe used data from the National Health and Nutrition Examination Survey 2005-2018. Weighted generalized linear regression analysis, Bayesian kernel machine regression, weighted quantile sum regression, mediation analysis, and network toxicology were employed to investigate the association between mixed exposures to perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate, and perfluorononanoic acid (PFNA) and lipids, as well as the atherogenic index of plasma (AIP), and to determine the impact of red blood cell folate or serum folate in the body.

resultsA positive association was detected between low density lipoprotein cholesterol (LDL-C) and PFOS; between total cholesterol (TC) and both PFOS and PFOA; between triglycerides (TG) and PFNA, PFOS, and PFOA; and between AIP and PFNA, PFOS, and PFOA. Analysis identified a positive correlation between mixed PFAS and LDL-C, TC, TG, and AIP. Red blood cell folate suppressed the associations of PFOA, PFOS, PFNA, and total PFAS with TG, as well as PFOA, PFOS, and total PFAS with AIP. The suppression effect of red blood cell folate was more pronounced in female adolescents. PFAS was associated with certain targets, including albumin, peroxisome proliferator-activated receptor γ, and interleukin-10, and may influence lipid metabolism and atherosclerosis. PFAS and folate share caspase-1 and carbonic anhydrase 2 as targets for mechanisms associated with atherosclerosis.

conclusionsPFAS exposure may be associated with dyslipidemia and impaired cardiovascular health in adolescents, while folate could potentially attenuate the direct association between PFAS exposure and these health outcomes. In the future, maintaining normal levels of folate in the body could be a key strategy in preventing disruptions to lipid metabolism and potential threats to cardiovascular health in adolescents caused by PFAS.

Indexed as

AtherosclerosisFluorocarbonsFolic AcidLipidsAdolescentAlkanesulfonic AcidsCaprylatesCholesterol, LDLErythrocytesFatty AcidsFemaleHumansMaleNutrition SurveysSulfonic AcidsTriglyceridesAlkanesulfonic AcidsCaprylatesCholesterol, LDLFatty AcidsFluorocarbonsFolic AcidLipidsperfluorohexanesulfonic acidperfluoro-n-nonanoic acidperfluorooctane sulfonic acidperfluorooctanoic acidSulfonic AcidsTriglyceridesAdolescentsAtherogenic index of plasmaFolateLipidsNational Health and Nutrition Examination SurveyPoly- and perfluoroalkyl substances

Identifiers

PMID40500729
PMCPMC12153114

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.