ArticleJournal of periodontal & implant science2026
Root coverage and patient-reported outcomes of de-epithelialized gingival graft with and without leukocyte platelet-rich fibrin in multiple recession defects: a split-mouth randomized trial.
Article in Journal of periodontal & implant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06509867 (The Clinical and Patient Morbidity Comparison of De-Epithelialized Gingival Graft With or Without Platelet Rich Fibrin in Multiple Gingival Recessions), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Clinical and Patient Morbidity Comparison of De-Epithelialized Gingival Graft With or Without Platelet Rich Fibrin in Multiple Gingival Recessions: A Split-mouth, Randomized Controlled Study
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study was conducted to compare the clinical efficacy and patient-reported outcomes of de-epithelialized gingival graft (DGG) alone versus DGG combined with leukocyte platelet-rich fibrin (L-PRF) for the treatment of multiple adjacent gingival recessions using a coronally advanced flap technique.
methodsIn this split-mouth randomized controlled trial, 15 patients with multiple gingival recessions affecting at least 3 adjacent teeth were treated on one side with DGG only (termed the DGG group) and on the contralateral side with DGG and L-PRF (the DGG+PRF group). Clinical parameters-recession depth, recession width, probing depth, clinical attachment level, keratinized tissue width, gingival thickness, and percentage of root coverage (RC%)-were recorded at 1 month, 3 months, and 6 months postoperatively. Patient-reported outcome measures, including Oral Health Impact Profile-14 scores, postoperative pain, bleeding, discomfort, and analgesic consumption, were also assessed.
resultsAt T6, the mean RC% was 93.30%±6.97% in the DGG group and 95.28%±4.99% in the DGG+PRF group, with no statistically significant difference observed. Patients receiving DGG+PRF reported significantly lower discomfort on days 2, 3, and 5 and reduced pain on days 6 and 7 relative to the DGG group.
conclusionsCombining L-PRF with DGG achieves root coverage outcomes comparable to DGG alone, while significantly reducing early postoperative discomfort and morbidity.
trial registrationClinicalTrials.gov Identifier: NCT06509867.
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