ArticleJournal of internal medicine2025
Prospective association between plasma amino acids and healthy aging in older adults.
Article in Journal of internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Review
- Comparative profiling of amino acids in plasma and serum across children and adults using LC-MS/MS and its implications for precision nutrition.Frontiers in nutrition · 2026Article
- Disruption of amino acid metabolism in acute cerebrovascular diseases: diagnostic and pathobiochemical perspectives.Frontiers in neurology · 2026Observational
- Prospective association between plasma amino acids and healthy aging in older adults.Journal of internal medicine · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundMost studies have compared plasma amino acids profiling across different age groups using a cross-sectional design, but no previous research has assessed the relationship between specific amino acid species and healthy aging.
objectivesThis study aims to explore the relationship between plasma concentrations of nine amino acids and healthy aging in an older Spanish population.
methodsThis longitudinal study uses data from the Seniors-ENRICA 2 Spanish cohort, which comprises community-dwelling individuals aged 65 and older. Plasma amino acid concentrations were measured at baseline and after a 5-year follow-up period (n = 859). Healthy aging has been defined as the delay on the onset of chronic conditions, optimal physical functioning, and no cognitive impairment. Multilevel mixed effect logistic models were used to examine the prospective association proposed, after adjusting for age, sex, socioeconomic status, and lifestyle behaviors.
resultsThe baseline mean age of the participants was 70.9 years (standard deviation [SD] = 4.0), and 51.6% were men. In the fully adjusted models, lower plasma concentrations of alanine [odds ratios per 1-SD increase (95% confidence interval) = 0.78 (0.72, 0.86)], isoleucine [0.70 (0.63, 0.78)], leucine [0.78 (0.71, 0.86)], and valine [0.79 (0.71, 0.86)] were prospectively associated with healthy aging (p-value < 0.001 in all cases). No significant associations were observed for glutamine, glycine, histidine, and aromatic amino acids.
conclusionLower concentrations of alanine and branched-chain amino acids were prospectively associated with healthy aging in the older population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.