Evidence mapPaperPMID 40501460Full record

ReviewWorld journal of hepatology2025

Sarcopenia and frailty: An in-depth analysis of the pathophysiology and effect on liver transplant candidates.

Grigorios Christodoulidis, Kyriaki Tsagkidou, Dimitra Bartzi, Ioana A Prisacariu, Eirini S Agko, Konstantinos E Koumarelas, Dimitrios Zacharoulis

Abstract readReview
In one paragraph

Review in World journal of hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Grigorios ChristodoulidisDepartment of General Surgery, University Hospital of Larissa, Larissa 41110, Thessalia, Greece. gregsurg@yahoo.gr.
Kyriaki TsagkidouDepartment of Gastroenterology, University Hospital of Larisa, Larisa 41100, Thessalia, Greece.
Dimitra BartziDepartment of Oncology, The 251 Airforce General Hospital, Athens 11525, Greece.
Ioana A PrisacariuDepartment of Rehabilitation, Luzerner Kantonsspital Wolhusen, Lucerne 6110, Luzern, Switzerland.
Eirini S AgkoDepartment of Intensive Care Unit, Asklepios Paulinen Clinic Wiesbaden, Wiesbaden 65197, Germany.
Konstantinos E KoumarelasDepartment of General and Orthopaedic Surgery, Luzerner Kantonsspital Wolhusen, Lucerne 6110, Luzern, Switzerland.
Dimitrios ZacharoulisDepartment of General Surgery, University of Thessaly, Larisa 41110, Thessalia, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cirrhosis represents the end stage of chronic liver disease, significantly reducing life expectancy as it progresses from a compensated to a decompensated state, leading to serious complications. Recent improvements in medical treatment have created a shift in cirrhosis management. Various causes, including hepatitis viruses, alcohol consumption, and fatty liver disease, contribute to cirrhosis and are closely linked to liver cancer. The disease develops through hepatocyte necrosis and regeneration, resulting in fibrosis and sinusoidal capillarization, leading to portal hypertension and complications such as ascites, hepatic encephalopathy, and organ dysfunction. Cirrhosis also holds an increased risk of hepatocellular carcinoma. Diagnosing cirrhosis involves assessing fibrosis scores through blood tests and measuring liver stiffness through elastography. Liver transplantation is the definitive treatment for end-stage liver disease and acute liver failure.

Indexed as

Artificial intelligenceChronic liver diseaseCirrhosisEnd-stage liver diseaseFrailtyLiver fibrosisLiver transplantMuscle mass lossPathophysiologySarcopenia

Identifiers

PMID40501460
PMCPMC12149904

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.