In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Obed O NyarkoIntegrative Physiology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-9184-6965 Ethan RauschDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Jared R H GoffUniversity of Utah Department of Internal Medicine.
Anis Karimpour-FardDepartment of Medicine, Division of General Internal Medicine, University of Colorado School of Medicine, Aurora, CO, 80045.ORCID 0000-0003-4249-4363 Caitlyn S ConardDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Laura Hernandez-LagunasDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
McKenna P A BurnsDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Brisa PeñaDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-4224-6626 Shelley D MiyamotoDepartment of Paediatrics, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-8029-981X Brian L StaufferDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-3418-7750 Carmen C SucharovDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-0349-1776 Funding
NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1MTranslational Pulmonary Vascular Biology ProgramT32HL007171 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Sonia Castro Flores, Tim Lahm · 1985 to 2026
$9.4MTargeting mitochondria in SV heart diseaseR01HL156670 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MIYAMOTO, SHELLEY DEANNE, STAUFFER, BRIAN L · 2021 to 2025
$3.9MInjectable Carbon Nanotube-Functionalized Hydrogel for miRNA DeliveryK25HL148386 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI PENA CASTELLANOS, BRISA MARISOL · 2020 to 2024
$891kInvestigations of Pathologic Remodeling Using Pediatric Heart Failure SerumK24HL150630 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SUCHAROV, CARMEN C · 2020 to 2024
$537kNCATS NIH HHS UL1 TR002535NHLBI NIH HHS K24 HL150630NHLBI NIH HHS K25 HL148386NHLBI NIH HHS R01 HL156670NHLBI NIH HHS T32 HL007171
6 · The paper itselfAbstract
Background: Paediatric Idiopathic dilated cardiomyopathy (iDCM) is a life-threatening disease. The lack of disease-specific animal models limits our understanding of its mechanisms. We previously demonstrated that paediatric iDCM serum-circulating proteins promote pathologic remodeling Methods: The effect of sFRP1 in combination with isoproterenol (ISO) (to recapitulate the increase in circulating catecholamine observed in paediatric iDCM) was evaluated in neonatal rat ventricular myocytes ( Results: We show that ISO+sFRP1 reactivates the fetal gene program Conclusion: We identified alterations in Notch and WNT signaling in paediatric iDCM hearts and in our model. Notch inhibition abrogated pathologic changes
Indexed as
dilated cardiomyopathyHeart failureNotchPaediatricstiffnessWNT
Identifiers
PMID40501561
PMCPMC12157673
What Socratic holds
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