Evidence map›Paper›PMID 40501670›Full record

ArticlebioRxiv : the preprint server for biology2025

A streamlined and comprehensive protocol for the generation and multi-omic analysis of human monocyte-derived macrophages.

Olivia G Palmer, Laurent Perreard, Fred W Kolling, Patricia A Pioli, Brittany A Goods

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Olivia G Palmer
Laurent Perreard
Fred W Kolling
Patricia A Pioli
Brittany A Goods

Funding

Zhao - Proj 2P20GM130454 · NIGMS · DARTMOUTH COLLEGE · PI MICHAEL L WHITFIELD · 2019 to 2026
$27.2M
Cellular Immunotherapy to Combat Fibrosis and Inflammation in Systemic SclerosisR21AI178651 · NIAID · DARTMOUTH COLLEGE · PI PIOLI, PATRICIA A., WHITFIELD, MICHAEL L · 2023 to 2024
$450k
NIAID NIH HHS R21 AI178651NIGMS NIH HHS P20 GM130454
6 · The paper itself

Abstract

Macrophages serve both as a first line of defense against invading pathogens and mediate tissue homeostasis. These cells are inherently responsive and heterogeneous and lie on a spectrum of activation states book-ended by M1-like (inflammatory) and M2-like (anti-inflammatory) extremes. The study of human macrophages is necessary to unravel the complex signals and environmental cues that these cells integrate to create their varied phenotypes.

Identifiers

PMID40501670
PMCPMC12154855

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.