Evidence map›Paper›PMID 40501676›Full record

ArticlebioRxiv : the preprint server for biology2025

A comprehensive mechanosensory connectome reveals a somatotopically organized neural circuit architecture controlling stimulus-aimed grooming of the

Steven A Calle-Schuler, Alexis E Santana-Cruz, Lucia Kmecová, Stefanie Hampel, Andrew M Seeds

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Steven A Calle-SchulerInstitute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico.ORCID 0000-0003-1304-585X
Alexis E Santana-CruzInstitute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico.ORCID 0000-0002-8162-8072
Lucia KmecováInstitute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico.
Stefanie HampelInstitute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico.ORCID 0000-0001-8287-549X
Andrew M SeedsInstitute of Neurobiology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico.ORCID 0000-0002-4932-6496

Funding

Upstream Regulation and Downstream effectors of c-MYC in Ovarian CancerU54MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Carmen M Velez Vega · 2017 to 2026
$35.8M
RISE Option III: MBRS RISE at the UPR Medical Sciences CampusR25GM061838 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CADILLA, CARMEN LYDIA · 2000 to 2021
$25.5M
The Role of Sensory Input to Mammalian Locomotion After the Loss of supraspinal.P20GM103642 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LASALDE-DOMINICCI, JOSE ANTONIO · 2013 to 2023
$20.6M
TRANSLATIONAL PROTEOMICS CENTERG12MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FERNANDEZ-REPOLLET, EMMA · 2012 to 2016
$11.0M
Research Projects CoreP30GM149367 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI JOSE Antonio LASALDE-DOMINICCI · 2023 to 2026
$5.6M
Crowdsourcing the Fly ConnectomeRF1MH117815 · NIMH · PRINCETON UNIVERSITY · PI MURTHY, MALA, SEUNG, HYUNJUNE SEBASTIAN · 2018 to 2018
$3.3M
High-resolution synaptic and functional connectivity mapping of a neural circuit architecture underlying a behavioral sequenceRF1NS121911 · NINDS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI SEEDS, ANDREW MICHAEL · 2021 to 2021
$1.4M
High-resolution synaptic and functional connectivity mapping of a neural circuit architecture underlying a behavioral sequenceR01NS121911 · NINDS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI SEEDS, ANDREW MICHAEL · 2024 to 2025
$893k
NIGMS NIH HHS P20 GM103642NIGMS NIH HHS P30 GM149367NIGMS NIH HHS R25 GM061838NIMHD NIH HHS G12 MD007600NIMHD NIH HHS U54 MD007600NIMH NIH HHS RF1 MH117815NINDS NIH HHS R01 NS121911NINDS NIH HHS RF1 NS121911
6 · The paper itself

Abstract

Animals respond to tactile stimulations of the body with location-appropriate behavior, such as aimed grooming. These responses are mediated by mechanosensory neurons distributed across the body, whose axons project into somatotopically organized brain regions corresponding to body location. How mechanosensory neurons interface with brain circuits to transform mechanical stimulations into location-appropriate behavior is unclear. We previously described the somatotopic organization of bristle mechanosensory neurons (BMNs) around the

Identifiers

PMID40501676
PMCPMC12154692

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.