Evidence map›Paper›PMID 40501737›Full record

ArticlebioRxiv : the preprint server for biology2025

Edin Muratspahić, David Feldman, David E Kim, Xiangli Qu, Ana-Maria Bratovianu, Paula Rivera-Sánchez, Federica Dimitri, Jason Cao, Brian P Cary, Matthew J Belousoff and 36 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

Edin MuratspahićDepartment of Biochemistry, University of Washington, Seattle, WA 98195.ORCID 0000-0002-6011-0805
David FeldmanDepartment of Biochemistry, University of Washington, Seattle, WA 98195.
David E KimDepartment of Biochemistry, University of Washington, Seattle, WA 98195.ORCID 0000-0002-0023-956X
Xiangli QuDepartment of Biochemistry, University of Washington, Seattle, WA 98195.
Ana-Maria BratovianuBioInnovation Institute, DK2200 Copenhagen N, Denmark.
Paula Rivera-SánchezBioInnovation Institute, DK2200 Copenhagen N, Denmark.
Federica DimitriBioInnovation Institute, DK2200 Copenhagen N, Denmark.
Jason CaoDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, VIC Australia.
Brian P CaryDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, VIC Australia.
Matthew J BelousoffDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, VIC Australia.
Peter KeovDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, VIC Australia.
Qingchao ChenMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.
Yue RenMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.
Justyn FineProgram in Molecular Biophysics, Johns Hopkins University, Baltimore, MD 21208, USA; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231, USA.
Isaac SappingtonDepartment of Biochemistry, University of Washington, Seattle, WA 98195.
Thomas SchlichthaerleDepartment of Biochemistry, University of Washington, Seattle, WA 98195.
Jason Z ZhangDepartment of Biochemistry, University of Washington, Seattle, WA 98195.
Arvind PillaiDepartment of Biochemistry, University of Washington, Seattle, WA 98195.
Ljubica MihaljevićDepartment of Biochemistry, University of Washington, Seattle, WA 98195.
Magnus BauerDepartment of Biochemistry, University of Washington, Seattle, WA 98195.
Susana Vázquez TorresDepartment of Biochemistry, University of Washington, Seattle, WA 98195.
Amir MotmaenDepartment of Biochemistry, University of Washington, Seattle, WA 98195.ORCID 0000-0003-4190-6215
Gyu Rie LeeDepartment of Biochemistry, University of Washington, Seattle, WA 98195.
Long TranInstitute for Protein Design, University of Washington, Seattle, WA 98195.
Xinru WangDepartment of Biochemistry, University of Washington, Seattle, WA 98195.
Inna GoreshnikDepartment of Biochemistry, University of Washington, Seattle, WA 98195.
Dionne K VafeadosDepartment of Biochemistry, University of Washington, Seattle, WA 98195.
Justin E SvendsenDepartment of Bioengineering, Knight Campus for Accelerating Scientific Impact, University of Oregon, 6231 University of Oregon, Eugene, OR, 97403, USA.
Parisa HosseinzadehDepartment of Bioengineering, Knight Campus for Accelerating Scientific Impact, University of Oregon, 6231 University of Oregon, Eugene, OR, 97403, USA.
Nicolai LindegaardNovo Nordisk A/S, Novo Nordisk Park 1, 2760 Måløv, Denmark.
Matthäus BrandtNovo Nordisk A/S, Novo Nordisk Park 1, 2760 Måløv, Denmark.
Yann WaltenspühlNovo Nordisk A/S, Novo Nordisk Park 1, 2760 Måløv, Denmark.
Kristine DeiblerNovo Nordisk A/S, Novo Nordisk Park 1, 2760 Måløv, Denmark.
Luke OostdykLeadHunter Services, Eurofins DiscoverX, LLC, CA-94583, California, USA.
William CaoLeadHunter Services, Eurofins DiscoverX, LLC, CA-94583, California, USA.
Lakshmi AnantharamanLeadHunter Services, Eurofins DiscoverX, LLC, CA-94583, California, USA.
Lance StewartDepartment of Biochemistry, University of Washington, Seattle, WA 98195.
Lauren HalloranDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Jamie B SpanglerDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD 21231, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Patrick M SextonDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, VIC Australia.
Bryan L RothDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and NIMH Psychoactive Drug Screening Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Brian E KrummDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and NIMH Psychoactive Drug Screening Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Denise WoottenDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, VIC Australia.
Christopher G TateMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.
Christoffer NornDepartment of Biochemistry, University of Washington, Seattle, WA 98195.ORCID 0000-0002-1450-4651
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA 98195.

Funding

STRUCTURE AND FUNCTION OF MRG-FAMILY RECEPTORSR01DA055656 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bryan L. Roth, Brian K Shoichet · 2022 to 2026
$2.8M
Designed Vehicles for Blood Brain Barrier TraversalR01AG063845 · NIA · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID · 2019 to 2023
$2.5M
Design of de novo interleukin mimics for targeted immunotherapyR01CA240339 · NCI · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID · 2019 to 2023
$2.1M
Engineered osteogenic growth factors for targeted stimulation of bone regenerationR21DE031436 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI GRAYSON, WARREN L, SPANGLER, JAMIE BERTA · 2022 to 2023
$435k
De novo designed Ras tools to uncover the mechanisms underlying drug resistanceK99CA293001 · NCI · UNIVERSITY OF WASHINGTON · PI ZHANG, JASON · 2024 to 2024
$110k
NCI NIH HHS K99 CA293001NCI NIH HHS R01 CA240339NIA NIH HHS R01 AG063845NIDA NIH HHS R01 DA055656NIDCR NIH HHS R21 DE031436
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) play key roles in physiology and are central targets for drug discovery and development, yet the design of protein agonists and antagonists has been challenging as GPCRs are integral membrane proteins and conformationally dynamic. Here we describe computational

Identifiers

PMID40501737
PMCPMC12157396

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.