Evidence map›Paper›PMID 40501779›Full record

ArticlebioRxiv : the preprint server for biology2025

Parkinson's Disease-vulnerable and -resilient dopamine neurons display opposite responses to excitatory input.

Lotfi C Hadjas, Grace J Kollman, Lexe Linderhof, Mingxuan Xia, Syon Mansur, Martine Saint-Pierre, Byung Kook Lim, Edward B Lee, Francesca Cicchetti, Rajeshwar Awatramani and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lotfi C HadjasUniversity of California, San Diego, Department of Neurosciences, La Jolla CA, USA.ORCID 0000-0003-1605-3601
Grace J KollmanUniversity of California, San Diego, Department of Neurosciences, La Jolla CA, USA.
Lexe LinderhofUniversity of California, San Diego, Department of Neurosciences, La Jolla CA, USA.
Mingxuan XiaAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase MD 20815, USA.
Syon MansurUniversity of California, San Diego, Department of Psychiatry, La Jolla CA, USA.
Martine Saint-PierreAxe Neurosciences, Centre de Recherche du CHU de Québec-Université Laval, Québec, QC, Canada.
Byung Kook LimNeurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-3766-5415
Edward B LeeDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Francesca CicchettiAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase MD 20815, USA.
Rajeshwar AwatramaniAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase MD 20815, USA.ORCID 0000-0002-0713-2140
Nick G HollonAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase MD 20815, USA.ORCID 0000-0003-4827-1582
Thomas S HnaskoUniversity of California, San Diego, Department of Neurosciences, La Jolla CA, USA.ORCID 0000-0001-6176-8513

Funding

Project IV: In Vivo Dissection of Genetic Modifiers on Different Stages of SynucleinopathyP01AG084497 · NIA · UNIVERSITY OF PENNSYLVANIA · PI ALICE S CHEN-PLOTKIN · 2024 to 2026
$15.2M
Substantia nigra circuits in instrumental actionR01NS138598 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Nick Garber Hollon · 2024 to 2026
$1.4M
NIA NIH HHS P01 AG084497NINDS NIH HHS R01 NS138598
6 · The paper itself

Abstract

Dopamine (DA) neurons of the substantia nigra (SN) are essential for motor control and selectively degenerate in Parkinson's disease (PD). However, DA neurons are molecularly heterogeneous, with some showing greater vulnerability and others resilience. Here, we show that the DA subtype marker

Identifiers

PMID40501779
PMCPMC12157410

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.