Evidence map›Paper›PMID 40501870›Full record

ArticlebioRxiv : the preprint server for biology2025

cGAS-STING dependent type I IFN protects against

Suman Gupta, James Matsunaga, Bridget Ratitong, Sana Ismaeel, Diogo G Valadares, A Phillip West, Nagaraj Kerur, Christian Stehlik, Andrea Dorfleutner, Jargalsaikhan Dagvadorj and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Suman GuptaDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
James MatsunagaResearch Service, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.
Bridget RatitongDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Sana IsmaeelDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Diogo G ValadaresDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
A Phillip WestThe Jackson Laboratory, Bar Harbor, Maine, USA.ORCID 0000-0003-2884-6895
Nagaraj KerurDepartment of Ophthalmology and Visual Sciences, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Christian StehlikDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Andrea DorfleutnerDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Jargalsaikhan DagvadorjDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Jenifer CoburnDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Andrea J WolfDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Suzanne L CasselDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
David A HaakeDivision of Infectious Diseases, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.
Fayyaz S SutterwalaDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0002-7338-3095

Funding

Virulence and Adaptation to the Host Environment of Pathogenic LeptospiraP01AI168148 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DAVID A HAAKE · 2023 to 2026
$11.8M
Type I Interferon Responses in the Pathobiology of Anthracycline-induced CardiotoxicityR01HL148153 · NHLBI · TEXAS A&M UNIVERSITY · PI John Travis Hinson, Andrew Phillip West · 2020 to 2026
$2.8M
Innate NLRC4 signaling controls adaptive immune responsesR01AI177233 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI Suzanne Cassel, Fayyaz S. Sutterwala · 2023 to 2026
$2.5M
Regulation of cellular functions and innate immunity by interleukin-1alphaR01AI175101 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI Jargalsaikhan Dagvadorj, Fayyaz S. Sutterwala · 2024 to 2026
$1.8M
NHLBI NIH HHS R01 HL148153NIAID NIH HHS P01 AI168148NIAID NIH HHS R01 AI175101NIAID NIH HHS R01 AI177233
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40501870
PMCPMC12157660

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.