In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
26 authors.
Mitchell R VollgerDivision of Medical Genetics, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0002-8651-1615 Elliott G SwansonDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0002-0351-6446 Shane J NephDivision of Medical Genetics, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0003-2962-8777 Jane RanchalisDivision of Medical Genetics, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0009-0004-1654-4114 Katherine M MunsonDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0001-8413-6498 Ching-Huang HoCenter for Systems Immunology, Benaroya Research Institute at Virginia Mason Franciscan Health, Seattle, WA, USA.ORCID 0000-0001-8359-8068 Y H Hank ChengDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Adriana E Sedeño-CortésDivision of Medical Genetics, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0001-7959-8970 Stephanie C BohaczukDivision of Medical Genetics, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0001-8802-6579 Maxwell A DippelCenter for Systems Immunology, Benaroya Research Institute at Virginia Mason Franciscan Health, Seattle, WA, USA.
Yizi MaoDivision of Medical Genetics, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0001-5743-6831 Nancy L ParmaleeCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA, USA.
Benjamin J MalloryDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0003-1572-6181 William T HarveyDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0003-0646-7528 Younjun KwonDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0002-5024-2134 Gage H GarciaDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0009-0005-2383-722X Kendra HoekzemaDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0002-8058-0177 Jeffrey G MeyerDepartment of Laboratory Medicine and Pathology, Mayo Clinic Hospital, Rochester, Minnesota, USA.
Mine CicekDepartment of Laboratory Medicine and Pathology, Mayo Clinic Hospital, Rochester, Minnesota, USA.
Evan E EichlerDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0002-8246-4014 William S NobleDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0001-7283-4715 Daniela M WittenDepartments of Statistics & Biostatistics, University of Washington, Seattle WA, USA.
James T BennettCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, and Department of Pediatrics, University of Washington, Seattle, WA, USA.ORCID 0000-0003-2843-5594 John P RayDepartment of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0001-7294-4260 Andrew B StergachisDivision of Medical Genetics, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0002-1299-3674 Funding
Northwest Genomics Center for All of UsOT2OD002748 · OD · UNIVERSITY OF WASHINGTON · PI EICHLER, EVAN, JARVIK, GAIL PAIRITZ · 2018 to 2023
$65.4MSomatic Mosaicism across Human Tissues Program: Genome Characterization Centers (GCC SMaHT)UM1DA058220 · NIDA · SEATTLE CHILDREN'S HOSPITAL · PI JAMES T BENNETT, Evan Eichler · 2023 to 2026
$15.2MMedical Genetics Training GrantT32GM007454 · NIGMS · UNIVERSITY OF WASHINGTON · PI Gail Pairitz Jarvik, Andrew Ben Stergachis · 1985 to 2026
$6.9MT cells promoting transitions toward autoimmunityU01AI176320 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI Jane Hoyt Buckner, S Alice Long · 2023 to 2026
$4.7MInvestigating Genetic and Epigenetic Control of T Cell Function in AutoimmunityDP2AI183504 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI John Philip Ray · 2023 to 2026
$2.6MInvestigating the contribution of non-coding genetic variation to rare disordersDP5OD029630 · OD · UNIVERSITY OF WASHINGTON · PI STERGACHIS, ANDREW BEN · 2020 to 2024
$1.9MTooling for accurately studying the epigenome along the human pangenome referenceU01HG013744 · NHGRI · UNIVERSITY OF WASHINGTON · PI STERGACHIS, ANDREW BEN · 2024 to 2024
$1.4MThe regulatory landscape of segmentally duplicated genes: Implications for human evolution and diseaseK99GM155552 · NIGMS · UNIVERSITY OF WASHINGTON · PI VOLLGER, MITCHELL R. · 2024 to 2025
$160kNHGRI NIH HHS U01 HG013744NIAID NIH HHS DP2 AI183504NIAID NIH HHS U01 AI176320NIDA NIH HHS UM1 DA058220NIGMS NIH HHS K99 GM155552NIGMS NIH HHS T32 GM007454NIH HHS DP5 OD029630NIH HHS OT2 OD002748
6 · The paper itselfAbstract
Diploid human cells contain two non-identical genomes, and differences in their regulation underlie human development and disease. We present Fiber-seq Inferred Regulatory Elements (FIRE) and show that FIRE provides a more comprehensive and quantitative snapshot of the accessible chromatin landscape across the 6 Gbp diploid human genome, overcoming previously known and unknown biases afflicting our existing regulatory element catalog. FIRE provides a comprehensive genome-wide map of haplotype-selective chromatin accessibility (HSCA), exposing novel imprinted elements that lack underlying parent-of-origin CpG methylation differences, common and rare genetic variants that disrupt gene regulatory patterns, gene regulatory modules that enable genes to escape X chromosome inactivation, and autosomal mitotically stable somatic epimutations. We find that the human leukocyte antigen (HLA) locus harbors the most HSCA in immune cells, and we resolve the specific transcription factor (TF) binding events disrupted by disease-associated variants within the HLA locus. Finally, we demonstrate that the regulatory landscape of a cell is littered with autosomal somatic epimutations that are propagated by clonal expansions to create mitotically stable and non-genetically deterministic chromatin alterations.
Identifiers
PMID40501892
PMCPMC12157683
What Socratic holds
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LicenceCC BY
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