Evidence map›Paper›PMID 40501979›Full record

ArticlebioRxiv : the preprint server for biology2025

WAGO-1 is a sexually dimorphic Argonaute protein required for proper germ granule structure and gametogenesis.

Acadia L DiNardo, Nicole A Kurhanewicz, Hannah R Wilson, Veronica Berg, Diana E Libuda

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Acadia L DiNardoInstitute of Molecular Biology, Department of Biology, University of Oregon, 1229 Franklin Blvd Eugene, OR 97403, USA.
Nicole A KurhanewiczInstitute of Molecular Biology, Department of Biology, University of Oregon, 1229 Franklin Blvd Eugene, OR 97403, USA.
Hannah R WilsonInstitute of Molecular Biology, Department of Biology, University of Oregon, 1229 Franklin Blvd Eugene, OR 97403, USA.
Veronica BergDepartment of Biology, University of Oregon, 1229 Franklin Blvd Eugene, OR 97403, USA.
Diana E LibudaInstitute of Molecular Biology, Department of Biology, University of Oregon, 1229 Franklin Blvd Eugene, OR 97403, USA.ORCID 0000-0002-4944-1814

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
DEVELOPMENTAL BIOLOGY TRAINING PROGRAMT32HD007348 · NICHD · UNIVERSITY OF OREGON · PI Chris Q Doe, KRYN STANKUNAS · 1989 to 2026
$6.8M
Recombination pathway and partner choices during meiosis - Admin supplement for purchase of a High Content Imaging System.R35GM128890 · NIGMS · UNIVERSITY OF OREGON · PI Diana Elizabeth Libuda · 2018 to 2026
$4.0M
Regulation of sexually dimorphic piRNA pathways in heat-induced infertilityR03HD110785 · NICHD · UNIVERSITY OF OREGON · PI KURHANEWICZ, NICOLE A · 2023 to 2024
$148k
NICHD NIH HHS R03 HD110785NICHD NIH HHS T32 HD007348NIGMS NIH HHS R35 GM128890NIH HHS P40 OD010440
6 · The paper itself

Abstract

Germ cell proliferation and proper genome inheritance are critical for maintaining fertility through generations. To promote proper germ cell development, small RNA pathways employ Argonaute proteins (AGOs) to modulate gene expression and protect against deleterious genomic elements while not silencing against self. Here we identify sexual dimorphisms in localization and function of protein structural features of the Argonaute WAGO-1 that affects sex-specific gene regulation during

Indexed as

ArgonautesC. elegansgametogenesisgerm cell developmentgerm granulesoogenesisPIWI pathwaysexual dimorphismssmall RNAsspermatogenesis

Identifiers

PMID40501979
PMCPMC12154906

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.