Evidence map›Paper›PMID 40501998›Full record

ArticlebioRxiv : the preprint server for biology2025

Amino acid sensing by the α-cell mitochondrial phosphoenolpyruvate cycle regulates intracellular Ca

Erli Jin, Hannah R Foster, Evgeniy Potapenko, Shih Ming Huang, Xinhang Dong, Jing W Hughes, Matthew J Merrins

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Erli JinDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0009-0002-9410-9738
Hannah R FosterDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0003-4683-6180
Evgeniy PotapenkoDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA.
Shih Ming HuangDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA.
Xinhang DongDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0009-0008-4712-519X
Jing W HughesDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-4397-8175
Matthew J MerrinsDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0003-1599-9227

Funding

Mitochondrial ADP privation: A unifying model for glucose-induced insulin secretion.R01DK127637 · YALE UNIVERSITY · 2025 to 2025
$685k
Metabolic signaling of the beta cell primary ciliumR01DK140365 · YALE UNIVERSITY · 2025 to 2025
$659k
Metabolic Functions of Pyruvate Kinase M2 in Pancreatic Beta-cellsR01DK113103 · UNIVERSITY OF WISCONSIN-MADISON · 2025 to 2025
$485k
Paracrine regulation of islet cell function by primary ciliaR01DK138974 · WASHINGTON UNIVERSITY · 2025 to 2025
$442k
BLRD VA I01 BX005113NIDDK NIH HHS R01 DK113103NIDDK NIH HHS R01 DK127637NIDDK NIH HHS R01 DK138974NIDDK NIH HHS R01 DK140365
6 · The paper itself

Abstract

Objective: Pancreatic islet α-cells are increasingly recognized as amino acid sensors for the organism, however the metabolic pathways that α-cells use to sense amino acids have not been identified. Building on our prior work in β-cells, we sought to determine whether the mitochondrial phosphoenolpyruvate (PEP) cycle is involved in α-cell amino acid sensing. Methods: To investigate amino acid regulation of α-cells at the cellular level, we measured intracellular Ca Results: The mitochondrial fuels glutamine/leucine antagonized alanine/arginine-stimulated Ca Conclusions: The α-cell mitochondrial PEP cycle senses glutamine/leucine and inhibits Katp channels similarly to β-cells, while restricting amino acid stimulated membrane depolarization and Ca

Indexed as

amino acid metabolismGlucagon secretionmitochondrial phosphoenolpyruvate carboxykinasepancreatic α-cellspyruvate kinase

Identifiers

PMID40501998
PMCPMC12154670

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.