ArticlebioRxiv : the preprint server for biology2025
Disruption of The Spinal Cord-Gut Axis Alters Gut Microbial Dynamics and Carbohydrate Cross-feeding.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
The spinal cord, a nexus for brain-body crosstalk, controls gut physiology and microbial homeostasis, but the underlying mechanisms remain unclear. Using genome-resolved longitudinal metagenomics in male and female C57BL/6 mice before and up to 6 months after disrupting the spinal cord-gut axis, we reconstructed over 6,500 microbial draft genomes. This "Mouse B6 Gut Catalog" improved or doubled species- and strain-level representation in other published catalogs. Impaired spinal cord-gut crosstalk induced persistent, sex-, time- and lesion-specific alterations in community composition, marked by a consistent loss of
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