Evidence map›Paper›PMID 40502165›Full record

ArticlebioRxiv : the preprint server for biology2025

Hyperglycemic state and fluid shear stress affect metastatic breast cancer cell migration via focal adhesion kinase.

Brandon D Riehl, Eunju Kim, Taylor Boudreaux, Osaira Ovando, Stephanie Vielmas-Duarte, Suyong Choi, Hamid Band, Lanju Mei, Diganta Dutta, Surabhi Chandra and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Brandon D RiehlDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Eunju KimDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Taylor BoudreauxDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Osaira OvandoDepartment of Biology, University of Nebraska at Kearney, Kearney, NE 68849, USA.
Stephanie Vielmas-DuarteDepartment of Biology, University of Nebraska at Kearney, Kearney, NE 68849, USA.
Suyong ChoiEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Hamid BandEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Lanju MeiDepartment of Engineering and Aviation Sciences, University of Maryland Eastern Shore, Princess Anne, MD 21853, USA.
Diganta DuttaDepartment of Physics, Astronomy, and Engineering, University of Nebraska at Kearney, Kearney, NE 68849, USA.
Surabhi ChandraDepartment of Biology, University of Nebraska at Kearney, Kearney, NE 68849, USA.
Jung Yul LimDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL L SORGEN · 2012 to 2026
$59.2M
ZINC FINGER-INSPIRED FLUORESCENT CHEMOSENSORSP20RR016469 · NCRR · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI EUDY, JAMES D · 2001 to 2011
$36.2M
The role of stress in the fetal origin of obesity and metabolic dysfunctionP20GM104320 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI ZEMPLENI, JANOS · 2014 to 2024
$24.9M
Targeted mass spectrometry approaches to understand CART processing and recepter interactionsP20GM113126 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI RAZAVI RIZI, MOHAMMAD · 2016 to 2025
$20.8M
Unexpected roles of phosphoinositides in the nucleusR35GM150504 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Suyong Choi · 2023 to 2026
$1.5M
NCRR NIH HHS P20 RR016469NIGMS NIH HHS P20 GM103427NIGMS NIH HHS P20 GM104320NIGMS NIH HHS P20 GM113126NIGMS NIH HHS R35 GM150504
6 · The paper itself

Abstract

We tested how the diabetes-related hyperglycemic condition affects the migration of highly metastatic triple-negative breast cancer (TNBC) cells, MDA-MB-231, under a physiological fluid shear environment. MDA-MB-231 cells displayed a significantly enhanced migratory behavior under a high glucose condition (25 mM) specifically when exposed to flow at 15 dyne/cm

Identifiers

PMID40502165
PMCPMC12154699

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.