Evidence map›Paper›PMID 40502172›Full record

ArticlebioRxiv : the preprint server for biology2025

Dendritic inhibition terminates plateau potentials in CA1 pyramidal neurons.

Lee O Vaasjo, Shawn Kotermanski, Tiya Patel, Hengyue J Shi, Robert Machold, Simon Chamberland

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Lee O VaasjoDepartment of Neuroscience, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Shawn KotermanskiDepartment of Neuroscience, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Tiya PatelDepartment of Neuroscience, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Hengyue J ShiDepartment of Neuroscience, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, 15260, USA.
Robert MacholdNeuroscience Institute, New York University Grossman School of Medicine, New York, NY 10016.
Simon ChamberlandDepartment of Neuroscience, Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, 15260, USA.

Funding

The role of genetic and activity dependent cues in the generation of 5HT3aR interneuron diversityP01NS074972 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RUDY, BERNARDO · 2012 to 2023
$15.5M
Synaptic and cellular mechanisms of neuronal synchronizationR00MH126157 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Simon Chamberland · 2024 to 2026
$747k
NIMH NIH HHS R00 MH126157NINDS NIH HHS P01 NS074972
6 · The paper itself

Abstract

In CA1 pyramidal neurons (CA1-PYRs), plateau potentials control synaptic plasticity and the emergence of place cell identity. Here, we show that dendritic inhibition terminates plateaus in an all-or-none manner. Plateaus were initially resistant to inhibition but became increasingly susceptible to termination as they progressed. Between two distinct subtypes of dendrite-targeting interneurons, OLM

Indexed as

dendriteshippocampusinhibitioninterneuronsplateau potentials

Identifiers

PMID40502172
PMCPMC12157498

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.