Evidence map›Paper›PMID 40502679›Full record

ArticleJournal of bone oncology2025

The metastatic role of the CXCL10-CXCR3 axis and its therapeutic potential in osteosarcoma.

Benjamin B Gyau, Junyan Wang, Xiang Chen, Margaret A Clement, Zoe D Man, Angela M Major, Mathew C Weiser, Jun Xu, John Hicks, Tsz-Kwong Man

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. CXCL10-induced chemotaxis ofMolecular therapy. Oncology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Benjamin B GyauDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Junyan WangDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Xiang ChenDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Margaret A ClementDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Zoe D ManDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Angela M MajorDepartment of Histological Research and Development, Texas Children's Hospital, Houston, TX, USA.
Mathew C WeiserAdvanced Cell Engineering and 3D Models Core, Baylor College of Medicine, Houston, TX, USA.
Jun XuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
John HicksDepartment of Pathology, Baylor College of Medicine, Houston, TX, USA.
Tsz-Kwong ManDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The CXCL10-CXCR3 axis regulates immunity, tumorigenesis, and metastasis in multiple cancers. Yet, its roles in osteosarcoma (OS), the predominant pediatric malignant bone tumor, are not fully defined. Our prior work has shown that elevated serum CXCL10 levels correlate with poor OS prognosis. The current study delves deeper by investigating how CXCL10-mediated CXCR3 signaling influences OS growth and metastatic spread.

Indexed as

AKTCXCL10CXCR3MetastasisOsteosarcomaPAK1

Identifiers

PMID40502679
PMCPMC12158615

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.