Evidence map›Paper›PMID 40502783›Full record

ArticleResearch square2025

Cannabinoid Receptor Type 1 Availability in Individuals with a History of Childhood Trauma: A Positron Emission Tomography Study.

Anahita Bassir Nia, Ardavan Mohammad Aghaei, Brian Pittman, Nachshon Korem, Deepak D'Souza, Marc Potenza, Ansel Hillmer, Mohini Ranganathan, Ilan Harpaz-Rotem

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anahita Bassir NiaYale University School of Medicine.ORCID 0000-0002-3890-3518
Ardavan Mohammad Aghaei
Brian PittmanYale School of Medicine.
Nachshon KoremYaly university.ORCID 0000-0003-1859-2668
Deepak D'SouzaYale University School of Medicine.ORCID 0000-0003-3141-1462
Marc PotenzaYale university.ORCID 0000-0002-6323-1354
Ansel HillmerYale University.ORCID 0000-0002-8105-1381
Mohini RanganathanYale University.ORCID 0000-0002-8412-2923
Ilan Harpaz-RotemYale University.ORCID 0000-0002-6066-9406

Funding

Imaging Brain Cannabinoid Receptors in Cannabis Dependence, Withdrawal and AbstinR21DA030702 · NIDA · YALE UNIVERSITY · PI D'SOUZA, DEEPAK CYRIL, SKOSNIK, PATRICK DAVID · 2011 to 2012
$456k
Imaging Brain Cannabinoid Receptors (CB1) in SchizophreniaR21MH094961 · NIMH · YALE UNIVERSITY · PI D'SOUZA, DEEPAK CYRIL · 2012 to 2013
$383k
CSRD VA I01 CX001538NIDA NIH HHS R21 DA030702NIMH NIH HHS R21 MH094961
6 · The paper itself

Abstract

Early life adversity has a lasting impact on the endocannabinoid (eCB) system based on animal models. However, the impact of early life adversity such as childhood trauma (CT) on the eCB system has not been thoroughly studied. We assessed the availability of cannabinoid receptor type 1 (CB1R) in individuals with CT compared to healthy controls without CT (HCs). Cannabinoid receptor type 1 (CB1R) availability was compared in adults with CT (N = 22) and age- and sex-matched HCs (n = 22), using positron emission tomography (PET) imaging with the CB1R-specific radiotracer [

Identifiers

PMID40502783
PMCPMC12154151

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.