ArticleGastroenterology research2025
Statins and the Risk of Colorectal Cancer in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
Article in Gastroenterology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between statin use and the risk of colorectal cancer in patients with inflammatory bowel disease: a systematic review and meta-analysis.Frontiers in immunology · 2025Pooled it
- Colorectal cancer in ulcerative colitis: unraveling mechanisms and advancing surveillance and chemoprevention.Frontiers in oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Statins are reported to reduce colorectal cancer (CRC) risk in the general population, but their effect on individuals with inflammatory bowel disease (IBD) remains uncertain. We aimed to evaluate the relationship between statin use and CRC risk in patients with IBD. Methods: A comprehensive review of the literature was conducted on PubMed, Web of Science, and EMBASE to evaluate the association between statin use and the development of CRC in patients with IBD. After deduplication, there were 324 studies screened, and those reporting odds ratios (ORs) or hazard ratios (HRs) for CRC risk in IBD patients using statins were included. The primary endpoints included the development of CRC (OR) and time to CRC (HR). A meta-analysis utilizing fixed or random-effects models, heterogeneity tests, and a funnel plot was performed in R (version 4.3.0) with alpha of 0.05. Results: This meta-analysis included seven studies involving 59,596 patients: three for OR (11,116 patients) and four for HR (48,480 patients). The pooled OR was 0.22 (95% confidence interval (CI): 0.01 - 7.81), suggesting 78% lower odds of CRC in statin users, though not statistically significant (P = 0.21), with potential publication bias. The pooled HR was 0.77 (95% CI: 0.63 - 0.94), indicating a significant 23% reduction in CRC hazard for statin users (P < 0.05), with low publication bias. Conclusion: Our meta-analysis showed that statin use is associated with a reduced risk of CRC in IBD, significant in HR-based but not in OR-based analysis. Large randomized controlled trials are needed to clarify the duration of statin use and their chemopreventive effects, independent of factors such as targeted therapy for chronic mucosal inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.