Evidence map›Paper›PMID 40503443›Full record

ArticleSynthetic and systems biotechnology2025

Highly efficient synthesis of the natural product β-himachalene in yeast and its potential as a novel anti-HSV-1 therapeutic agent.

Qian Yang, Yutong Zhang, Pan Feng, Hui Zhang, Kai Wang, Biqiang Chen, Tianwei Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthetic and systems biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qian YangState Key Laboratory of Green Biomanufacturing, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.
Yutong ZhangState Key Laboratory of Green Biomanufacturing, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.
Pan FengState Key Laboratory of Green Biomanufacturing, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.
Hui ZhangState Key Laboratory of Green Biomanufacturing, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.
Kai WangState Key Laboratory of Green Biomanufacturing, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.
Biqiang ChenState Key Laboratory of Green Biomanufacturing, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.
Tianwei TanState Key Laboratory of Green Biomanufacturing, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Terpenoids, a high-value natural product family in nature, have garnered significant attention due to their diverse pharmaceutical activities. However, the current supply of most structurally complex terpenoids relies predominantly on plant extraction, and supply insufficiency has become a critical challenge. In this study, targeting the sesquiterpene synthase

Indexed as

Fusion proteinHerpes simplex virus (HSV-1)Metabolic engineeringPromoter engineeringSaccharomyces cerevisiaeβ-himachalene

Identifiers

PMID40503443
PMCPMC12152333

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.