Evidence map›Paper›PMID 40503593›Full record

ArticleBrain and behavior2025

Theta-Beta/Gamma Coupling Identifies Bothersome Tinnitus Induced by Thalamocortical Dysrhythmia.

Ying Wang, Jiajia Zhang, Xuan Huang, Shujian Huang, Yanmei Feng, Haibo Shi, Hui Wang, Richard Salvi, Shankai Yin

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PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Tinnitus.Nature reviews. Disease primers · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ying WangDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-1644-295X
Jiajia ZhangDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xuan HuangDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shujian HuangDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yanmei FengDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Haibo ShiDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hui WangDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Richard SalviShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, China.
Shankai YinDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

National Natural Science Foundation of China 82071041National Natural Science Foundation of China 82271161Young Scientists Fund of the National Natural Science Foundation of China 82101220
6 · The paper itself

Abstract

backgroundThe phantom sound of tinnitus can be an extremely debilitating condition. The thalamocortical dysrhythmia (TCD) hypothesis is a feature of subjective tinnitus; however, its consistency in characterizing different types of tinnitus remains unclear.

methodWe compared theta-beta/gamma coupling in multichannel EEG recordings from subjects with bothersome tinnitus (BT), non-bothersome tinnitus (NBT), and healthy controls (HC). Additionally, we used these EEG features to distinguish BT from NBT by employing the k-nearest neighbor (KNN) model.

resultsTheta-beta/gamma phase-amplitude coupling (PAC) was enhanced in the auditory cortex of both BT and NBT groups compared to HC. In contrast, theta-beta/gamma PAC was specifically enhanced in the cingulate gyrus and parahippocampal gyrus in the BT group. Notably, theta-gamma PAC in the orbitofrontal cortex was attenuated in the BT group and showed a negative correlation with their THI scores. By integrating theta-beta/gamma PAC into a machine learning algorithm, up to 92% of BT patients were accurately identified.

conclusionTCD in BT patients was characterized by enhanced theta-beta/gamma PAC in the auditory cortex, cingulate gyrus, and parahippocampal gyrus and attenuated theta-gamma PAC in the orbitofrontal cortex. The latter was significantly negatively correlated with THI scores. These PAC features, which could objectively distinguish BT patients by machine learning, may support the specificity of PAC features in tinnitus characterization.

Indexed as

Beta RhythmGamma RhythmThalamusTheta RhythmTinnitusAdultAgedAuditory CortexElectroencephalographyFemaleGyrus CinguliHumansMaleMiddle Aged

Identifiers

PMID40503593
PMCPMC12159765

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.