ArticleJournal of clinical laboratory analysis2025
Mitochondrial tRNA
Article in Journal of clinical laboratory analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mitochondrial tRNA-Derived Diseases.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundSequence alternations in mitochondrial genomes, especially in mitochondrial tRNA (mt-tRNA), are closely related to type 2 diabetes mellitus (T2DM); however, the detailed molecular mechanism is still largely undetermined.
methodsHerein, we reported a T2DM Chinese family by using molecular and biochemical analyses. The mtDNA mutations in this pedigree were detected by PCR and Sanger sequencing. Moreover, phylogenetic analysis was used to assess the pathogenic mitochondrial DNA (mtDNA) mutation. We further evaluated mt-tRNA stability levels and mitochondrial functions in cybrids with and without the m.14687A>G mutation.
resultsMembers of this family expressed variable clinical phenotypes. Screening for the entire mitochondrial genomes revealed the occurrence of a novel m.14687A>G mutation, which was located at position 60 in the TψC loop of tRNA
conclusionOur finding revealed that the novel m.14687A>G mutation resulted in aberrant mt-tRNA metabolism and mitochondrial dysfunctions, which should be regarded as a pathogenic mutation for T2DM.
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Registered trials
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