Evidence map›Paper›PMID 40503831›Full record

ArticleMicrobiology spectrum2025

Hyperoside inhibits PRRSV proliferation via the TLR4/NF-κB and p62-Nrf2-Keap1 signaling pathways, mediating inflammation and autophagy.

Tongtong Wang, Li Chen, Anqi Wang, Yulin Xu, Yuyu Zhang, Qin Zhao, Qinghai Ren, Sidang Liu, Liangliang Li, Yubao Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tongtong Wang *Key Laboratory of Livestock and Poultry Multiomics of MARA, Shandong Academy of Agricultural Sciences, Institute of Animal Science and Veterinary Medicine, Jinan, Shandong, China.ORCID 0009-0007-3999-3184
Li Chen *College of Agriculture and Biology, Liaocheng University, Liaocheng, China.
Anqi Wang *College of Agriculture and Biology, Liaocheng University, Liaocheng, China.
Yulin XuKey Laboratory of Livestock and Poultry Multiomics of MARA, Shandong Academy of Agricultural Sciences, Institute of Animal Science and Veterinary Medicine, Jinan, Shandong, China.
Yuyu ZhangKey Laboratory of Livestock and Poultry Multiomics of MARA, Shandong Academy of Agricultural Sciences, Institute of Animal Science and Veterinary Medicine, Jinan, Shandong, China.
Qin ZhaoDepartment of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
Qinghai RenCollege of Agriculture and Biology, Liaocheng University, Liaocheng, China.ORCID 0009-0001-4788-6983
Sidang LiuCollege of Animal Science and Technology, Shandong Agricultural University, Tai'an, China.
Liangliang LiCollege of Agriculture and Biology, Liaocheng University, Liaocheng, China.ORCID 0000-0001-5431-9103
Yubao LiCollege of Agriculture and Biology, Liaocheng University, Liaocheng, China.ORCID 0000-0002-8533-5015
Jiaqiang WuKey Laboratory of Livestock and Poultry Multiomics of MARA, Shandong Academy of Agricultural Sciences, Institute of Animal Science and Veterinary Medicine, Jinan, Shandong, China.ORCID 0000-0001-9160-9951

Funding

Shandong provincial natural science foundation ZR2024MC162
6 · The paper itself

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) causes abortion and respiratory disease in swine, hindering the development of the pig farming industry worldwide. However, at present, there are no effective vaccines or drugs for PRRSV control. In this study, we evaluated the inhibitory effect of hyperoside on PRRSV replication

Indexed as

Antiviral AgentsAutophagyPorcine Reproductive and Respiratory SyndromePorcine respiratory and reproductive syndrome virusQuercetinSignal TransductionAnimalsCell LineCytokinesInflammationKelch-Like ECH-Associated Protein 1Macrophages, AlveolarNF-E2-Related Factor 2NF-kappa BSwineToll-Like Receptor 4Antiviral AgentsCytokineshyperosideKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2NF-kappa BQuercetinToll-Like Receptor 4anti-inflammatory agentautophagyhyperosidePRRSV inhibitor

Identifiers

PMID40503831
PMCPMC12323607

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.