ArticleESC heart failure2025
Proteins associated with rehospitalization, mortality and diuretic resistance in acutely decompensated heart failure.
Article in ESC heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Metrics of left ventricular active relaxation reflect proteomic myocardial remodelling and reverse remodelling.ESC heart failure · 2026Article
- Predictive accuracy of serum IL-6, IL-17 and sST2 levels for diuretic resistance in patients with chronic heart failure.BMC cardiovascular disorders · 2026Article
- Acetazolamide effects on natriuresis and diuresis in acute heart failure treated with furosemide and SGLT2i (SANDI).ESC heart failure · 2026Observational
- Evaluation of Body Position Association with Diuretic Response and Neurohormonal Activation in Patients with Acutely Decompensated Heart Failure.Biomedicines · 2026Article
- Large-Scale Protein Assay Identifies Novel Protein Biomarkers Associated With Arterial Stiffness and Vascular Calcification Measures.International journal of hypertension · 2026Article
- Proteins associated with rehospitalization, mortality and diuretic resistance in acutely decompensated heart failure.ESC heart failure · 2025Article
- Low Dose GLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling in HFpEF Independent of Weight Loss.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
aimsMost proteomic analyses in patients with heart failure (HF) focus on the stable ambulatory setting; pathways that drive acute decompensated heart failure (ADHF) are largely uncharacterized. We aimed to examine the associations of cardiometabolic proteins with HF rehospitalization, mortality and diuretic response in patients with ADHF.
methodsThe Mechanisms of Diuretic Resistance Cohort comprised patients hospitalized for ADHF at Yale New Haven Hospital from 2015 to 2020. We quantified 369 serum proteins and evaluated their associations with rehospitalization, mortality or diuretic response, using individual and combined biomarkers. Models adjusted for sociodemographic/lifestyle factors, comorbidities and clinical factors. For individual biomarker models, significant proteins were those with a false-discovery rate q-value (FDRq) <1%, while combined biomarker models used a penalized cross-validated log-likelihood method to reduce false positives.
resultsOf 401 patients enrolled, median age was 65 years; 36% were female. Six (C1QTNF1, CTSD, FCN2, SERPINA12, TFRC and TNFRSF10C) were associated with increased risk of HF rehospitalization [hazard ratio (HR) ranging from 1.2 to 1.35 per standard deviation (SD) protein concentration] while one (SDC1) was associated with decreased risk (HR = 0.77 per SD protein concentration). Three (CDH1, FABP6 and TNC) were associated with mortality (HR ranging from 1.35 to 1.64 per SD protein concentration). Three (MMP7, PGLYRP1 and REN) were associated with reduced diuretic response (% Estimate ranging from -12.2% to -18.6% per SD protein concentration). Among all proteins, those associated with lower diuretic response correlated with greater mortality risk [Spearman r = -0.63 (95% confidence interval: -0.56, -0.69)].
conclusionsSeveral proteins with known associations with cardiometabolic disease were associated with poor outcomes or reduced diuretic response. They have known roles in inflammatory, metabolic and cardiac or kidney remodelling pathways and may point to novel pathways in ADHF that warrant investigation as potential prognostic tools and targets for intervention.
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