Evidence map›Paper›PMID 40504147›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Generative prediction of causal gene sets responsible for complex traits.

Benjamin Kuznets-Speck, Buduka K Ogonor, Thomas P Wytock, Adilson E Motter

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Fluctuation structure predicts genome-wide perturbation outcomes.bioRxiv : the preprint server for biology · 2025
    Article
  7. Generative prediction of causal gene sets responsible for complex traits.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Benjamin Kuznets-SpeckDepartment of Physics and Astronomy, Northwestern University, Evanston, IL 60208.ORCID 0000-0001-9859-8749
Buduka K OgonorDepartment of Physics and Astronomy, Northwestern University, Evanston, IL 60208.ORCID 0000-0002-3606-3172
Thomas P WytockDepartment of Physics and Astronomy, Northwestern University, Evanston, IL 60208.ORCID 0000-0001-5204-1064
Adilson E MotterDepartment of Physics and Astronomy, Northwestern University, Evanston, IL 60208.ORCID 0000-0003-1794-4828

Funding

STINGing GBM: A First-in- Man Clinical Trial in Surgical Resectable Recurrent GBMP50CA221747 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Hui Zhang · 2018 to 2026
$21.4M
HHS | National Institutes of Health (NIH) P50-CA221747National Science Foundation (NSF) MCB-2206974NCI NIH HHS P50 CA221747
6 · The paper itself

Abstract

The relationship between genotype and phenotype remains an outstanding question for organism-level traits because these traits are generally

Indexed as

Multifactorial InheritanceTranscriptomeGene Expression ProfilingGenome-Wide Association StudyGenotypeHumansMachine LearningModels, GeneticPhenotypeQuantitative Trait Locibiological networkscomplex systemsgenerative deep learninggene regulatory networksnonlinear dynamics

Identifiers

PMID40504147
PMCPMC12184495

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.