Evidence map›Paper›PMID 40504162›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Local and distal changes in dynamics are caused by an L205R Cushing's syndrome mutant in PRKACA.

Anagha Kalle, Jian Wu, Caesar Tawfeeq, Alexandr P Kornev, Gianluigi Veglia, Rodrigo Maillard, Susan S Taylor, Nisha Amarnath Jonniya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anagha Kalle *Advanced Academic Program, Johns Hopkins University, Washington, DC 20001.ORCID 0009-0002-7189-1042
Jian Wu *Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093.
Caesar TawfeeqDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093.
Alexandr P KornevDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0002-1543-3795
Gianluigi VegliaDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0002-2795-6964
Rodrigo MaillardDepartment of Chemistry, Georgetown University, Washington, DC 20007.ORCID 0000-0001-5078-6775
Susan S TaylorDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92093.ORCID 0000-0002-7702-6108
Nisha Amarnath JonniyaDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92093.

Funding

Lessons Learned from PKA: Assembly of Dynamic Macromolecular SwitchesR35GM130389 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUSAN S. TAYLOR · 2019 to 2026
$5.7M
Structural and dynamic basis for PRKACA-dependent signalopathiesR01CA290129 · NCI · UNIVERSITY OF MINNESOTA · PI Gianluigi Veglia · 2024 to 2026
$1.6M
HHS | NIH | All of Us Research Program (AoURP) CA290129HHS | NIH | All of Us Research Program (AoURP) GM130389NCI NIH HHS R01 CA290129NIGMS NIH HHS R35 GM130389
6 · The paper itself

Abstract

Cushing's syndrome (CS) is an abnormal condition characterized by elevated cortisol levels, often resulting from genetic alterations in the

Indexed as

Cushing SyndromeCyclic AMP-Dependent Protein Kinase Catalytic SubunitsMutationHumansMolecular Dynamics SimulationProtein ConformationCyclic AMP-Dependent Protein Kinase Catalytic SubunitsPRKACA protein, humanCushing’s syndromeL205R mutationlocal spatial patternmolecular dynamic simulationsPKA

Identifiers

PMID40504162
PMCPMC12184650

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.