Evidence map›Paper›PMID 40504257›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025

Association of cardiorespiratory fitness with HR-pQCT bone parameters in older adults: the Study of Muscle, Mobility and Aging (SOMMA).

Nina Z Heilmann, Kerri S Freeland, Reagan E Garcia, Nancy W Glynn, Lauren S Roe, Tong Yu, Nicole M Sekel, Kristen J Koltun, Katelyn I Guerriere, Julie M Hughes and 8 more

Abstract read
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. HR-pQCT skeletal phenotype clustering associated with muscle function in older men and women: The Study of Muscle, Mobility and Aging (SOMMA).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Nina Z HeilmannDepartment of Epidemiology, School of Public Health, University of Pittsburgh, 130 N. Bellefield Avenue, Suite 300, Pittsburgh, PA, USA.
Kerri S FreelandDepartment of Epidemiology, School of Public Health, University of Pittsburgh, 130 N. Bellefield Avenue, Suite 300, Pittsburgh, PA, USA.
Reagan E GarciaDepartment of Epidemiology, School of Public Health, University of Pittsburgh, 130 N. Bellefield Avenue, Suite 300, Pittsburgh, PA, USA.
Nancy W GlynnDepartment of Epidemiology, School of Public Health, University of Pittsburgh, 130 N. Bellefield Avenue, Suite 300, Pittsburgh, PA, USA.
Lauren S RoeDepartment of Epidemiology, School of Public Health, University of Pittsburgh, 130 N. Bellefield Avenue, Suite 300, Pittsburgh, PA, USA.
Tong YuDepartment of Epidemiology, School of Public Health, University of Pittsburgh, 130 N. Bellefield Avenue, Suite 300, Pittsburgh, PA, USA.
Nicole M SekelNeuromuscular Research Laboratory/Warrior Human Performance Research Center, Department of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA, USA.
Kristen J KoltunNeuromuscular Research Laboratory/Warrior Human Performance Research Center, Department of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA, USA.
Katelyn I GuerriereMilitary Performance Division, United States Army Research Institute of Environmental Medicine, Natick, MA, USA.
Julie M HughesMilitary Performance Division, United States Army Research Institute of Environmental Medicine, Natick, MA, USA.
Bradley C NindlNeuromuscular Research Laboratory/Warrior Human Performance Research Center, Department of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA, USA.
Ashley A WeaverSchool of Biomedical Engineering and Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Paolo CaserottiDepartment of Sports Science and Clinical Biomechanics and the Center for Active and Healthy Ageing, University of Southern Denmark, Odense, Denmark.
Peggy M CawthonSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, CA, USA.
Paul M CoenTranslational Research Institute, AdventHealth, Orlando, FL, USA.
Anne B NewmanDepartment of Epidemiology, School of Public Health, University of Pittsburgh, 130 N. Bellefield Avenue, Suite 300, Pittsburgh, PA, USA.
Jane A CauleyDepartment of Epidemiology, School of Public Health, University of Pittsburgh, 130 N. Bellefield Avenue, Suite 300, Pittsburgh, PA, USA.
Elsa S StrotmeyerDepartment of Epidemiology, School of Public Health, University of Pittsburgh, 130 N. Bellefield Avenue, Suite 300, Pittsburgh, PA, USA. strotmeyere@edc.pitt.edu.ORCID http://orcid.org/0000-0002-4093-6036

Funding

Study of Muscle, Mobility and Aging: SOMMA2R01AG059416 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI STEVEN RON CUMMINGS, Peggy Mannen Cawthon · 2018 to 2026
$70.3M
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI STEPHEN B. KRITCHEVSKY · 2002 to 2026
$36.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
TRAINING IN THE EPIDEMIOLOGY OF AGINGT32AG000181 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 1989 to 2025
$6.2M
Muscle Quantity, Quality, Function, and Biomarker Associations with Longitudinal Preservation of Bone Microarchitecture and Bone Strength in Older AdultsR01AR086541 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE ANN, STROTMEYER, ELSA S. · 2025 to 2025
$1.6M
Bone microarchitecture and bone strength relationships to muscle quantity, quality and function in older adultsR01AR076752 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAULEY, JANE ANN, STROTMEYER, ELSA S. · 2019 to 2023
$1.5M
Claude D. Pepper Older Americans Independence Center, University of Pittsburgh P30AG024827Claude Pepper Older Americans Independence Center, Wake Forest School of Medicine P30AG021332NCATS NIH HHS UL1 TR001420NIAMS NIH HHS R01 AR076752NIAMS NIH HHS R01 AR086541NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG059416NIA NIH HHS T32 AG000181Wake Forest Clinical and Translational Science Institute, Wake Forest School of Medicine UL1 0TR001420
6 · The paper itself

Abstract

Higher cardiorespiratory fitness may be associated with better bone health in older age, though this has not been investigated using state-of-the-science VO

introductionMaintaining cardiorespiratory fitness among older adults holds potential benefits for bone health, though this association has not been investigated using gold-standard measures of VO

methodsParticipants included 123 men (age 76.2 ± 4.4 years, 93% White) and 188 women (age 76.1 ± 4.7 years, 87% White) in the Study of Muscle, Mobility and Aging (SOMMA). Absolute peak oxygen consumption (VO

resultsIn men, higher VO

conclusionsAssociations of VO

Indexed as

AgingBone DensityCardiorespiratory FitnessAbsorptiometry, PhotonAgedAged, 80 and overAnthropometryExercise TestFemaleHumansMaleOxygen ConsumptionSex FactorsTibiaTomography, X-Ray ComputedAgingBMDDXAFitnessHR-pQCTVO2peak

Identifiers

PMID40504257
PMCPMC12353959

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.