Evidence mapPaperPMID 40504372Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Nephroprotective activity of Eysenhardtia polystachya through antioxidant, H

Emiliano de Jesús Parra-Espejel, Samara Jennifer Hipólito-Jiménez, Melissa Daniela Galicia González, Diana Montes Rojas, Viridiana Gisela Llera-Rojas, Josué A Velázquez-Moyado

Abstract read
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emiliano de Jesús Parra-EspejelFacultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Mexico City, 04510, México.
Samara Jennifer Hipólito-JiménezFacultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Mexico City, 04510, México.
Melissa Daniela Galicia GonzálezFacultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Mexico City, 04510, México.
Diana Montes RojasFacultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Mexico City, 04510, México.
Viridiana Gisela Llera-RojasFacultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Mexico City, 04510, México.
Josué A Velázquez-MoyadoFacultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Mexico City, 04510, México. josue_moyado@quimica.unam.mx.ORCID http://orcid.org/0000-0003-1892-2989

Funding

Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México IA208721PAIP, Universidad Nacional Autónoma de México PAIP5000-9186
6 · The paper itself

Abstract

In Mexico, the use of infusions from Eysenhardtia polystachya in traditional medicine as a treatment for chronic inflammatory pathologies, such as urinary disorders, diabetes, and oxidative stress has been studied in the search for bioactive molecules with pharmacological properties. In this study, a methanolic extract was obtained from which Coatline B and Matlaline molecules were isolated and identified. Their pharmacological activity was subsequently evaluated as potential nephroprotective agents using both in vivo and in vitro models of acute kidney injury (AKI). The experimental results indicated that the Coatline B and Matlaline compounds exhibit antioxidant activity and play a role in nitric oxide (NO) and hydrogen sulfide (H

Indexed as

Acute Kidney InjuryAntioxidantsHydrogen SulfideNitric OxidePlant ExtractsAnimalsDisease Models, AnimalHumansKidneyMaleMiceRatsRats, WistarAntioxidantsHydrogen SulfideNitric OxidePlant ExtractsChronic kidney diseaseCoatline BEysenhardtia polystachyaHydrogen sulfideInflammationIschemia–reperfusionMatlalineNephroprotectiveNitric oxide

Identifiers

PMID40504372
PMCPMC12678624

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.