Evidence map›Paper›PMID 40504754›Full record

ArticleAmerican journal of respiratory and critical care medicine2025

Metabolomic Evidence of Biological Overlap with Heart Failure with Preserved Ejection Fraction in a Subset of Pulmonary Arterial Hypertension.

Yogesh N V Reddy, Aneesh K Asokan, Robert P Frantz, Anna Hemnes, Paul M Hassoun, John Barnard, Evelyn Horn, Jane A Leopold, Franz Rischard, Erika B Rosenzweig and 11 more

Abstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Yogesh N V ReddyDepartment of Cardiovascular Medicine and.
Aneesh K AsokanDivision of Endocrinology, Diabetes, and Nutrition, Mayo Clinic, Rochester, Minnesota.
Robert P FrantzDepartment of Cardiovascular Medicine and.
Anna HemnesDivision of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0002-2755-5845
Paul M HassounDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.
John BarnardDepartment of Quantitative Health Sciences and.
Evelyn HornPerkin Heart Failure Center, Division of Cardiology, Weill Cornell Medicine, New York, New York.
Jane A LeopoldDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Franz RischardDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, Arizona.
Erika B RosenzweigDepartment of Pediatrics and Medicine, Columbia University, New York, New York.
Nicholas S HillDivision of Pulmonary, Critical Care, and Sleep Medicine, Tufts Medical Center, Boston, Massachusetts; and.
Serpil C ErzurumLerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Gerald J BeckDepartment of Quantitative Health Sciences and.
J Emanuel FinetLerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Gabriele GrunigDepartment of Environmental Medicine, New York University Grossman School of Medicine, New York, New York.
Christine L JellisLerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Stephen C MathaiDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0003-3188-7209
Catherine E SimpsonDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland.ORCID 0000-0002-2388-5660
W H Wilson TangLerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
K Sreekumaran NairDivision of Endocrinology, Diabetes, and Nutrition, Mayo Clinic, Rochester, Minnesota.
Barry A BorlaugDepartment of Cardiovascular Medicine and.

Funding

Pulmonary Vascular Disease Phenomics Program (PVDOMICS) Data Coordinating CenterU01HL125177 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BECK, GERALD J, ERZURUM, SERPIL C. · 2014 to 2020
$20.0M
Pulmonary Hypertension in Left Heart DiseaseR01HL162828 · NHLBI · MAYO CLINIC ROCHESTER · PI Barry A. Borlaug, Margaret M Redfield · 2023 to 2026
$3.1M
HL-Inorganic Nitrite to Enhance Benefits from Exercise Training in Heart Failure with preserved Ejection FractionR01HL128526 · NHLBI · MAYO CLINIC ROCHESTER · PI BORLAUG, BARRY A. · 2016 to 2019
$2.4M
Mayo Clinic HeartShare Clinical CenterU01HL160226 · NHLBI · MAYO CLINIC ROCHESTER · PI Barry A. Borlaug, Margaret M Redfield · 2021 to 2026
$1.8M
Intergrated Endothelial Phenotyping to Redefine Pulmonary HypertensionU01HL125215 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEOPOLD, JANE A, WAXMAN, AARON B · 2014 to 2018
$1.7M
PVDOMICS Defining the Future Fingerprints of Pulmonary Vascular DiseaseU01HL125218 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BERMAN-ROSENZWEIG, ERIKA S., HORN, EVELYN · 2014 to 2018
$1.6M
Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics: Clinical Centers (CC) (U01).U01HL125205 · NHLBI · MAYO CLINIC ROCHESTER · PI FRANTZ, ROBERT PAUL · 2014 to 2018
$1.5M
A molecular phenotype of combined pulmonary hypertensionU01HL125212 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HEMNES, ANNA R, NEWMAN, JOHN HUGHES · 2014 to 2018
$1.5M
Phenomic and genomic study to subphenotype Hispanics with pulmonary hypertensionU01HL125208 · NHLBI · UNIVERSITY OF ARIZONA · PI GARCIA, JOE G. N., RISCHARD, FRANZ P · 2014 to 2018
$1.5M
Hopkins Clinical Center for Pulmonary Vascular Disease Phenomics ProgramU01HL125175 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HASSOUN, PAUL M., MATHAI, STEPHEN C · 2015 to 2019
$1.1M
Peripheral Limitations in Pulmonary Hypertension and Effects of Muscle TrainingK23HL164901 · NHLBI · MAYO CLINIC ROCHESTER · PI Yogesh Nellore Vilambi Reddy · 2023 to 2026
$671k
NHLBI NIH HHS K23 HL164901NHLBI NIH HHS K23HL164901NHLBI NIH HHS R01 HL128526NHLBI NIH HHS R01 HL162828NHLBI NIH HHS U01 HL125175NHLBI NIH HHS U01 HL125177NHLBI NIH HHS U01 HL125205NHLBI NIH HHS U01 HL125208NHLBI NIH HHS U01 HL125212NHLBI NIH HHS U01 HL125215NHLBI NIH HHS U01 HL125218NHLBI NIH HHS U01 HL160226
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Heart FailureHypertension, PulmonaryMetabolomeMetabolomicsPulmonary Arterial HypertensionStroke VolumeAgedCase-Control StudiesFemaleHumansMaleMiddle AgedSerotoninSerotoninhemodynamicsHFpEFmetabolomicspulmonary hypertension

Identifiers

PMID40504754
PMCPMC12432440

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.