SynthesisJournal of global health2025
Adverse childhood experiences contribute to blood pressure changes in adulthood: a meta-analysis of over 750 000 adults.
Synthesis in Journal of global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Observational
- Identification of Mental Health Disorder Symptoms, Predisposing Factors and their Impact on Quality of Life in Young Hypertensive Patients: A Multicenter Longitudinal Study.Clinical practice and epidemiology in mental health : CP & EMH · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Adverse childhood experiences (ACE) have been linked to various negative health outcomes in adulthood. However, their relationship with blood pressure remains inconclusive. We aimed to conduct a systematic review and meta-analysis to investigate this association. Methods: We conducted a comprehensive search of PubMed, Cochrane Library, Scopus, Web of Science, China National Knowledge Infrastructure, Wanfang Data, and VIP from the databases' inception until 1 July 2023. We assessed the quality of included cross-sectional and cohort studies using the Agency of Healthcare Research and Quality and Newcastle-Ottawa Scale criteria. We analysed the combined effect size for the diagnosis of hypertension and changes in systolic blood pressure and diastolic blood pressure from the included studies further explored these results based on geographical and age subgroups. Results: We included a total of 19 cohort and 23 cross-sectional studies, comprising 754 146 participants and investigating 24 types of ACE. In addition to parental divorce or separation and group violence, exposure to domestic violence, physical neglect, and physical abuse were associated with an increased risk of hypertension, with the risk increasing with the number of exposures. This association was prominent in Europe and North America and in adults. However, the relationship varied among Asian populations and minors due to the type and degree of ACE. Conclusions: Our results provide evidence supporting the association between ACE and elevated blood pressure, suggesting that ACE may contribute to the development of hypertension in adulthood. Future studies should explore potential gender differences in this association. Registration: PROSPERO: CRD42023442287.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.