ArticleScience (New York, N.Y.)2025
Rapid model-guided design of organ-scale synthetic vasculature for biomanufacturing.
Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- 3D bioprinting of tissues and organs for systemic diseases and localized injuries.Military Medical Research · 2026Review
- Computational Modeling of Collateral Circulation and Arteriolar Vasodilation in Ischemic Tissue Perfusion.Annals of biomedical engineering · 2026Article
- Clinical trials in a dish: cardiometabolic drug development with biological and digital twins.The Journal of clinical investigation · 2026Review
- Tomographic Printing in a Chip: A Versatile Platform for Biomimetic 3D Organ-on-Chip.Advanced healthcare materials · 2026Article
- Vascularized bone organoids: current advances and a biomimetic platform for osteonecrosis of the femoral head.Bone research · 2026Review
- Bioprinted vascularized soft-tissue flaps with an integrated arterial-venous loop.Cell biomaterials · 2026Article
- 3D bioprinting in liver transplantation: from organ replacement to transplantable functional support.Hepatobiliary surgery and nutrition · 2026Article
- Challenges and opportunities in generating microvasculature using bioprinting techniques.npj biomedical innovations · 2026Review
- Topological Tracks Patterned via 3D Printing Vascularize Murine Organ-Scale Constructs.Cell biomaterials · 2026Article
- Computational approaches in bioprinting processes.Nature reviews bioengineering · 2026Article
- Photothermal Ablation Blotting for Capillary-Scale Microvasculature Engineering.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Bioinstructive Orthogonally-crosslinked Ovoprotein Microgels for Modular Bioprinting.bioRxiv : the preprint server for biology · 2026Article
- Computational design of artificial supply networks for engineered human tissue.Scientific reports · 2026Article
- Hybrid bioprinting of hierarchical vascular networks at capillary-scale resolution.Nature chemical engineering · 2026Article
- Organoids: generation strategies, applications, and future challenges.Stem cell research & therapy · 2026Review
- Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling.Advanced healthcare materials · 2026Review
- Digital twins and digital models of the human circulatory system.Nature reviews bioengineering · 2026Article
- Whole organism 3D mapping reveals universal branching topology and biophysical optimization governs vascular and nervous system development.bioRxiv : the preprint server for biology · 2026Article
- Vascularized Cardiac Tissue Engineering: From Advances in Biofabrication to Translational Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- 3D biofabricated in vitro models as new approach methodologies for animal alternatives.npj biomedical innovations · 2026Review
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Authors and funding
15 authors.
Funding
Abstract
Our ability to produce human-scale biomanufactured organs is limited by inadequate vascularization and perfusion. For arbitrarily complex geometries, designing and printing vasculature capable of adequate perfusion poses a major hurdle. We introduce a model-driven design platform that demonstrates rapid synthetic vascular model generation alongside multifidelity computational fluid dynamics simulations and three-dimensional bioprinting. Key algorithmic advances accelerate vascular generation 230-fold and enable application to arbitrarily complex shapes. We demonstrate that organ-scale vascular network models can be generated and used to computationally vascularize >200 engineered and anatomic models. Synthetic vascular perfusion improves cell viability in fabricated living-tissue constructs. This platform enables the rapid, scalable vascular model generation and fluid physics analysis for biomanufactured tissues that are necessary for future scale-up and production.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.