Evidence map›Paper›PMID 40505619›Full record

ReviewCell host & microbe2025

Metabolic ecology of microbiomes: Nutrient competition, host benefits, and community engineering.

Erik Bakkeren, Vit Piskovsky, Kevin R Foster

Abstract readReview
In one paragraph

Review in Cell host & microbe, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Review
  3. Enhanced Endophytic Colonization of Flavobacterium Promotes Plant Resistance to Fusarium Wilt.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Polyphosphate synthesis is essential for phosphate and ATP homeostasis during nutrient upshift.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. High bacterial diversity drives the suppression of a soilborne plant disease.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Erik BakkerenSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK. Electronic address: erik.bakkeren@ucalgary.ca.
Vit PiskovskySir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK; Department of Mathematics, University of Oxford, Oxford OX2 6GG, UK.
Kevin R FosterSir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK. Electronic address: kevin.foster@path.ox.ac.uk.

Funding

Wellcome Trust 209397
6 · The paper itself

Abstract

Many plants and animals, including humans, host diverse communities of microbes that provide many benefits. A key challenge in understanding microbiomes is that the species composition often differs among individuals, which can thwart generalization. Here, we argue that the key to identifying general principles for microbiome science lies in microbial metabolism. In the human microbiome and in other systems, every microbial species must find ways to harvest nutrients to thrive. The available nutrients in a microbiome interact with microbial metabolism to define which species have the potential to persist in a host. The resulting nutrient competition shapes other mechanisms, including bacterial warfare and cross-feeding, to define microbiome composition and properties. We discuss impacts on ecological stability, colonization resistance, nutrient provision for the host, and evolution. A focus on the metabolic ecology of microbiomes offers a powerful way to understand and engineer microbiomes in health, agriculture, and the environment.

Indexed as

BacteriaHost Microbial InteractionsMicrobiotaNutrientsAnimalsHumansPlantsNutrientsbacterial warfarecolonization resistancecommunity assemblycommunity engineeringcommunity stabilitycross-feedinggutmicrobiomenutrient competitionpathogens

Identifiers

PMID40505619
PMCPMC7618682

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.