Evidence map›Paper›PMID 40506673›Full record

ReviewInflammopharmacology2025

Cold responses and hormonal echoes: a comprehensive view of Raynaud's vascular dysfunction.

Manal Fardoun, Odette El Ghawi, Christie Dib, Leen Jaradi, Marie Therese Chaddad, Hassan Dehaini, Ali H Eid

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Manal Fardoun *Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Odette El Ghawi *Faculty of Medicine, University of Balamand, El Koura, Lebanon.
Christie DibFaculty of Medicine, University of Balamand, El Koura, Lebanon.
Leen JaradiFaculty of Medicine, University of Balamand, El Koura, Lebanon.
Marie Therese ChaddadFaculty of Medicine, University of Balamand, El Koura, Lebanon.
Hassan DehainiCase Western Reserve University, The MetroHealth System, Cleveland, OH, USA.
Ali H EidDepartment of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, PO Box 2713, Doha, Qatar. ali.eid@qu.edu.qa.ORCID http://orcid.org/0000-0003-3004-5675

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Raynaud's phenomenon is a peripheral vascular disorder characterized by exaggerated vasoconstrictive response to certain stimuli, most typically cold exposure and emotional stress. Interestingly, Raynaud's phenomenon incidence is significantly higher in premenopausal females compared to age-matched males, highlighting a role of the female hormone, estrogen, in Raynaud's phenomenon pathogenesis. Indeed, estrogen plays a fundamental role in potentiating the expression and function of α

Indexed as

Cold TemperatureEstrogensRaynaud DiseaseAnimalsFemaleHumansMaleReceptors, Adrenergic, alpha-2Risk FactorsVasoconstrictionEstrogensReceptors, Adrenergic, alpha-2Adrenergic receptorsArteriolesCold-induced constrictionPeripheral vascular diseaseThermoregulation

Identifiers

PMID40506673
PMCPMC12354549

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.