Evidence map›Paper›PMID 40507003›Full record

ReviewDiagnostics (Basel, Switzerland)2025

The Lung Microbiome and Its Impact on Obstructive Sleep Apnea: A Diagnostic Frontier.

Aliki Karkala, Serafeim-Chrysovalantis Kotoulas, Asterios Tzinas, Eleni Massa, Eleni Mouloudi, Foteini Gkakou, Athanasia Pataka

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aliki KarkalaRespiratory Failure Unit, General Hospital of Thessaloniki "G. Papanikolaou", Exochi, 57010 Thessaloniki, Greece.ORCID 0000-0003-2730-0532
Serafeim-Chrysovalantis KotoulasIntensive Care Unit, "Hippokration" Hospital of Thessaloniki, 54642 Thessaloniki, Greece.ORCID 0000-0002-6092-1341
Asterios TzinasRespiratory Failure Unit, General Hospital of Thessaloniki "G. Papanikolaou", Exochi, 57010 Thessaloniki, Greece.ORCID 0000-0003-3899-5624
Eleni MassaIntensive Care Unit, "Hippokration" Hospital of Thessaloniki, 54642 Thessaloniki, Greece.
Eleni MouloudiIntensive Care Unit, "Hippokration" Hospital of Thessaloniki, 54642 Thessaloniki, Greece.
Foteini GkakouDepartment of Pulmonology, General Hospital of Thessaloniki "G. Papanikolaou", Exochi, 57010 Thessaloniki, Greece.
Athanasia PatakaRespiratory Failure Unit, General Hospital of Thessaloniki "G. Papanikolaou", Exochi, 57010 Thessaloniki, Greece.ORCID 0000-0002-3252-6694

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obstructive sleep apnea (OSA), a prevalent disorder characterized by recurrent upper airway collapse, is increasingly recognized as a systemic inflammatory condition influenced by microbial dysregulation. Emerging evidence underscores the lung microbiome as a mediator in OSA pathophysiology, where dysbiotic shifts driven by intermittent hypoxia, oxidative stress and mechanical airway trauma amplify inflammatory cascades and perpetuate respiratory instability. This review synthesizes current knowledge on the bidirectional interplay between OSA and lung microbial communities. It aims to highlight how hypoxia-induced alterations in microbial ecology disrupt immune homeostasis, while inflammation-driven mucosal injury fosters pathogenic colonization. Clinical correlations between specific taxa like

Indexed as

dysbiosislower respiratory tractlung microbiomeobstructive sleep apnea

Identifiers

PMID40507003
PMCPMC12154070

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.