Evidence mapPaperPMID 40507315Full record

ReviewCancers2025

A Critical Review of Immunomodulation in the Management of Inoperable Stage III NSCLC.

Kimberly Burcher, Pooja Karukonda, Christopher Kelsey, Trey Mullikin, Scott J Antonia, Eziafa I Oduah

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kimberly BurcherDuke Cancer Institute, Durham, NC 27710, USA.
Pooja KarukondaDuke Cancer Institute, Durham, NC 27710, USA.
Christopher KelseyDuke Cancer Institute, Durham, NC 27710, USA.
Trey MullikinDuke Cancer Institute, Durham, NC 27710, USA.
Scott J AntoniaDuke Cancer Institute, Durham, NC 27710, USA.
Eziafa I OduahDuke Cancer Institute, Durham, NC 27710, USA.ORCID 0000-0001-8517-6360

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current standard of care for inoperable stage III non-small cell lung cancer (NSCLC) is concurrent chemotherapy and radiation therapy with consolidation durvalumab. Despite this approach, about 50% of patients will experience disease recurrence, with about half of recurrence events occurring at distant metastatic sites. In this review, the authors performed a structured analysis of the available clinical trial data and literature related to the treatment of this disease. The authors discuss the detriments and merits of several of these trials and explore clinical and preclinical data that contribute to the growing body of literature supporting a future with new approaches, including new techniques in radiation therapy, sequencing, and agents. Upcoming trials may illuminate a path towards better outcomes for patients in this setting.

Indexed as

immunomodulationimmunotherapynon-small cell lung cancer

Identifiers

PMID40507315
PMCPMC12153929

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.